VEGF Blockade Decreases Tumor Uptake of Systemic Oncolytic Herpes Virus but Enhances Therapeutic Efficacy When Given After Virotherapy

Effective therapies for metastatic sarcomas remain elusive. Oncolytic viruses have shown promise as anticancer agents, but their access to metastatic sites following systemic delivery is low. Because systemic delivery of small molecule chemotherapy is enhanced by prior treatment with anti-angiogenic...

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Detalles Bibliográficos
Autores principales: Eshun, Francis K., Currier, Mark A., Gillespie, Rebecca A., Fitzpatrick, Jillian L., Baird, William H., Cripe, Timothy P.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900405/
https://www.ncbi.nlm.nih.gov/pubmed/20508601
http://dx.doi.org/10.1038/gt.2010.82

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