Cargando…

Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis

BACKGROUND: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. RESULTS: Incremental...

Descripción completa

Detalles Bibliográficos
Autores principales: Steinwald, Paul M, Whang, Kevin T, Becker, Kenneth L, Snider, Richard H, Nylen, Eric S, White, Jon C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29007/
https://www.ncbi.nlm.nih.gov/pubmed/11056717
_version_ 1782119943702052864
author Steinwald, Paul M
Whang, Kevin T
Becker, Kenneth L
Snider, Richard H
Nylen, Eric S
White, Jon C
author_facet Steinwald, Paul M
Whang, Kevin T
Becker, Kenneth L
Snider, Richard H
Nylen, Eric S
White, Jon C
author_sort Steinwald, Paul M
collection PubMed
description BACKGROUND: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. RESULTS: Incremental increases in doses of bacteria resulted in proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml). Gel filtration studies revealed that ProCT was the predominant (> 90%) molecular form of serum iCT secreted. In the metabolic experiments, total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium. CONCLUSIONS: In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels.
format Text
id pubmed-29007
institution National Center for Biotechnology Information
language English
publishDate 1999
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-290072001-03-22 Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis Steinwald, Paul M Whang, Kevin T Becker, Kenneth L Snider, Richard H Nylen, Eric S White, Jon C Crit Care Research Paper BACKGROUND: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. RESULTS: Incremental increases in doses of bacteria resulted in proportional increases in 72h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21 pg/ml). Gel filtration studies revealed that ProCT was the predominant (> 90%) molecular form of serum iCT secreted. In the metabolic experiments, total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium. CONCLUSIONS: In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels. BioMed Central 1999 1999-03-15 /pmc/articles/PMC29007/ /pubmed/11056717 Text en Copyright © 1999 Current Science Ltd
spellingShingle Research Paper
Steinwald, Paul M
Whang, Kevin T
Becker, Kenneth L
Snider, Richard H
Nylen, Eric S
White, Jon C
Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
title Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
title_full Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
title_fullStr Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
title_full_unstemmed Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
title_short Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
title_sort elevated calcitonin precursor levels are related to mortality in an animal model of sepsis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29007/
https://www.ncbi.nlm.nih.gov/pubmed/11056717
work_keys_str_mv AT steinwaldpaulm elevatedcalcitoninprecursorlevelsarerelatedtomortalityinananimalmodelofsepsis
AT whangkevint elevatedcalcitoninprecursorlevelsarerelatedtomortalityinananimalmodelofsepsis
AT beckerkennethl elevatedcalcitoninprecursorlevelsarerelatedtomortalityinananimalmodelofsepsis
AT sniderrichardh elevatedcalcitoninprecursorlevelsarerelatedtomortalityinananimalmodelofsepsis
AT nylenerics elevatedcalcitoninprecursorlevelsarerelatedtomortalityinananimalmodelofsepsis
AT whitejonc elevatedcalcitoninprecursorlevelsarerelatedtomortalityinananimalmodelofsepsis