Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

Hypomorphic RAG mutations, leading to limited V(D)J rearrangements, cause Omenn syndrome (OS), a peculiar severe combined immunodeficiency associated with autoimmune-like manifestations. Whether B cells play a role in OS pathogenesis is so far unexplored. Here we report the detection of plasma cells...

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Detalles Bibliográficos
Autores principales: Cassani, Barbara, Poliani, Pietro Luigi, Marrella, Veronica, Schena, Francesca, Sauer, Aisha V., Ravanini, Maria, Strina, Dario, Busse, Christian E., Regenass, Stephan, Wardemann, Hedda, Martini, Alberto, Facchetti, Fabio, van der Burg, Mirjam, Rolink, Antonius G., Vezzoni, Paolo, Grassi, Fabio, Traggiai, Elisabetta, Villa, Anna
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901059/
https://www.ncbi.nlm.nih.gov/pubmed/20547828
http://dx.doi.org/10.1084/jem.20091928

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