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Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis
A20 is a nuclear factor κB (NF-κB) target gene that encodes a ubiquitin-editing enzyme that is essential for the termination of NF-κB activation after tumor necrosis factor (TNF) or microbial product stimulation and for the prevention of TNF-induced apoptosis. Mice lacking A20 succumb to inflammatio...
Autores principales: | Vereecke, Lars, Sze, Mozes, Guire, Conor Mc, Rogiers, Brecht, Chu, Yuanyuan, Schmidt-Supprian, Marc, Pasparakis, Manolis, Beyaert, Rudi, van Loo, Geert |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901067/ https://www.ncbi.nlm.nih.gov/pubmed/20530205 http://dx.doi.org/10.1084/jem.20092474 |
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