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GABAergic Synapse Properties May Explain Genetic Variation in Hippocampal Network Oscillations in Mice
Cognitive ability and the properties of brain oscillation are highly heritable in humans. Genetic variation underlying oscillatory activity might give rise to differences in cognition and behavior. How genetic diversity translates into altered properties of oscillations and synchronization of neuron...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901093/ https://www.ncbi.nlm.nih.gov/pubmed/21082021 http://dx.doi.org/10.3389/fncel.2010.00018 |
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author | Heistek, Tim S. Jaap Timmerman, A. Spijker, Sabine Brussaard, Arjen B. Mansvelder, Huibert D. |
author_facet | Heistek, Tim S. Jaap Timmerman, A. Spijker, Sabine Brussaard, Arjen B. Mansvelder, Huibert D. |
author_sort | Heistek, Tim S. |
collection | PubMed |
description | Cognitive ability and the properties of brain oscillation are highly heritable in humans. Genetic variation underlying oscillatory activity might give rise to differences in cognition and behavior. How genetic diversity translates into altered properties of oscillations and synchronization of neuronal activity is unknown. To address this issue, we investigated cellular and synaptic mechanisms of hippocampal fast network oscillations in eight genetically distinct inbred mouse strains. The frequency of carbachol-induced oscillations differed substantially between mouse strains. Since GABAergic inhibition sets oscillation frequency, we studied the properties of inhibitory synaptic inputs (IPSCs) received by CA3 and CA1 pyramidal cells of three mouse strains that showed the highest, lowest and intermediate frequencies of oscillations. In CA3 pyramidal cells, the frequency of rhythmic IPSC input showed the same strain differences as the frequency of field oscillations. Furthermore, IPSC decay times in both CA1 and CA3 pyramidal cells were faster in mouse strains with higher oscillation frequencies than in mouse strains with lower oscillation frequency, suggesting that differences in GABA(A)-receptor subunit composition exist between these strains. Indeed, gene expression of GABA(A)-receptor β2 (Gabrb2) and β3 (Gabrb2) subunits was higher in mouse strains with faster decay kinetics compared with mouse strains with slower decay kinetics. Hippocampal pyramidal neurons in mouse strains with higher oscillation frequencies and faster decay kinetics fired action potential at higher frequencies. These data indicate that differences in genetic background may result in different GABA(A)-receptor subunit expression, which affects the rhythm of pyramidal neuron firing and fast network activity through GABA synapse kinetics. |
format | Text |
id | pubmed-2901093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29010932010-08-19 GABAergic Synapse Properties May Explain Genetic Variation in Hippocampal Network Oscillations in Mice Heistek, Tim S. Jaap Timmerman, A. Spijker, Sabine Brussaard, Arjen B. Mansvelder, Huibert D. Front Cell Neurosci Neuroscience Cognitive ability and the properties of brain oscillation are highly heritable in humans. Genetic variation underlying oscillatory activity might give rise to differences in cognition and behavior. How genetic diversity translates into altered properties of oscillations and synchronization of neuronal activity is unknown. To address this issue, we investigated cellular and synaptic mechanisms of hippocampal fast network oscillations in eight genetically distinct inbred mouse strains. The frequency of carbachol-induced oscillations differed substantially between mouse strains. Since GABAergic inhibition sets oscillation frequency, we studied the properties of inhibitory synaptic inputs (IPSCs) received by CA3 and CA1 pyramidal cells of three mouse strains that showed the highest, lowest and intermediate frequencies of oscillations. In CA3 pyramidal cells, the frequency of rhythmic IPSC input showed the same strain differences as the frequency of field oscillations. Furthermore, IPSC decay times in both CA1 and CA3 pyramidal cells were faster in mouse strains with higher oscillation frequencies than in mouse strains with lower oscillation frequency, suggesting that differences in GABA(A)-receptor subunit composition exist between these strains. Indeed, gene expression of GABA(A)-receptor β2 (Gabrb2) and β3 (Gabrb2) subunits was higher in mouse strains with faster decay kinetics compared with mouse strains with slower decay kinetics. Hippocampal pyramidal neurons in mouse strains with higher oscillation frequencies and faster decay kinetics fired action potential at higher frequencies. These data indicate that differences in genetic background may result in different GABA(A)-receptor subunit expression, which affects the rhythm of pyramidal neuron firing and fast network activity through GABA synapse kinetics. Frontiers Research Foundation 2010-06-02 /pmc/articles/PMC2901093/ /pubmed/21082021 http://dx.doi.org/10.3389/fncel.2010.00018 Text en Copyright © 2010 Heistek, Timmerman, Spijker, Brussaard and Mansvelder. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Heistek, Tim S. Jaap Timmerman, A. Spijker, Sabine Brussaard, Arjen B. Mansvelder, Huibert D. GABAergic Synapse Properties May Explain Genetic Variation in Hippocampal Network Oscillations in Mice |
title | GABAergic Synapse Properties May Explain Genetic Variation in Hippocampal Network Oscillations in Mice |
title_full | GABAergic Synapse Properties May Explain Genetic Variation in Hippocampal Network Oscillations in Mice |
title_fullStr | GABAergic Synapse Properties May Explain Genetic Variation in Hippocampal Network Oscillations in Mice |
title_full_unstemmed | GABAergic Synapse Properties May Explain Genetic Variation in Hippocampal Network Oscillations in Mice |
title_short | GABAergic Synapse Properties May Explain Genetic Variation in Hippocampal Network Oscillations in Mice |
title_sort | gabaergic synapse properties may explain genetic variation in hippocampal network oscillations in mice |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901093/ https://www.ncbi.nlm.nih.gov/pubmed/21082021 http://dx.doi.org/10.3389/fncel.2010.00018 |
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