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Recombination analysis reveals a double recombination event in hepatitis E virus
Recombination of Hepatitis E Virus (HEV) has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 134 complete HEV genomes. Three potentially significant recombination events, including both intra-genotype and one inter-genotype, were identified by re...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901267/ https://www.ncbi.nlm.nih.gov/pubmed/20546601 http://dx.doi.org/10.1186/1743-422X-7-129 |
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author | Wang, Hua Zhang, Wen Ni, Bin Shen, Hongxing Song, Yuyu Wang, Xiaochun Shao, Shihe Hua, Xiuguo Cui, Li |
author_facet | Wang, Hua Zhang, Wen Ni, Bin Shen, Hongxing Song, Yuyu Wang, Xiaochun Shao, Shihe Hua, Xiuguo Cui, Li |
author_sort | Wang, Hua |
collection | PubMed |
description | Recombination of Hepatitis E Virus (HEV) has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 134 complete HEV genomes. Three potentially significant recombination events, including both intra-genotype and one inter-genotype, were identified by recombination detection analysis. Recombination events I and II occurred intra-genotype and inter-genotype, respectively, among three isolates, including the lineage represented by CHN-XJ-SW13 (GU119961, swine isolate), E067-SIJ05C (AB369690, human isolate), and JJT-Kan (AB091394, human isolate), and lead to the recombinant swine isolate swCH31 (DQ450072). Recombination event III occurred between the lineage represented by the NA1 (M73218) and K52-87 (L25595), which resulted in the recombinant Xingjiang-1 (D11092). Our analyses proved that that recombination could occur between human and swine HEV strains, double recombination events existed in HEV, and recombination event could happen within ORF2 region of HEV. These results will provide valuable hints for future research on HEV diversity. |
format | Text |
id | pubmed-2901267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29012672010-07-10 Recombination analysis reveals a double recombination event in hepatitis E virus Wang, Hua Zhang, Wen Ni, Bin Shen, Hongxing Song, Yuyu Wang, Xiaochun Shao, Shihe Hua, Xiuguo Cui, Li Virol J Short Report Recombination of Hepatitis E Virus (HEV) has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 134 complete HEV genomes. Three potentially significant recombination events, including both intra-genotype and one inter-genotype, were identified by recombination detection analysis. Recombination events I and II occurred intra-genotype and inter-genotype, respectively, among three isolates, including the lineage represented by CHN-XJ-SW13 (GU119961, swine isolate), E067-SIJ05C (AB369690, human isolate), and JJT-Kan (AB091394, human isolate), and lead to the recombinant swine isolate swCH31 (DQ450072). Recombination event III occurred between the lineage represented by the NA1 (M73218) and K52-87 (L25595), which resulted in the recombinant Xingjiang-1 (D11092). Our analyses proved that that recombination could occur between human and swine HEV strains, double recombination events existed in HEV, and recombination event could happen within ORF2 region of HEV. These results will provide valuable hints for future research on HEV diversity. BioMed Central 2010-06-14 /pmc/articles/PMC2901267/ /pubmed/20546601 http://dx.doi.org/10.1186/1743-422X-7-129 Text en Copyright ©2010 Wang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Wang, Hua Zhang, Wen Ni, Bin Shen, Hongxing Song, Yuyu Wang, Xiaochun Shao, Shihe Hua, Xiuguo Cui, Li Recombination analysis reveals a double recombination event in hepatitis E virus |
title | Recombination analysis reveals a double recombination event in hepatitis E virus |
title_full | Recombination analysis reveals a double recombination event in hepatitis E virus |
title_fullStr | Recombination analysis reveals a double recombination event in hepatitis E virus |
title_full_unstemmed | Recombination analysis reveals a double recombination event in hepatitis E virus |
title_short | Recombination analysis reveals a double recombination event in hepatitis E virus |
title_sort | recombination analysis reveals a double recombination event in hepatitis e virus |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901267/ https://www.ncbi.nlm.nih.gov/pubmed/20546601 http://dx.doi.org/10.1186/1743-422X-7-129 |
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