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Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus

Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fat...

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Autores principales: Palacios, Gustavo, Lovoll, Marie, Tengs, Torstein, Hornig, Mady, Hutchison, Stephen, Hui, Jeffrey, Kongtorp, Ruth-Torill, Savji, Nazir, Bussetti, Ana V., Solovyov, Alexander, Kristoffersen, Anja B., Celone, Christopher, Street, Craig, Trifonov, Vladimir, Hirschberg, David L., Rabadan, Raul, Egholm, Michael, Rimstad, Espen, Lipkin, W. Ian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901333/
https://www.ncbi.nlm.nih.gov/pubmed/20634888
http://dx.doi.org/10.1371/journal.pone.0011487
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author Palacios, Gustavo
Lovoll, Marie
Tengs, Torstein
Hornig, Mady
Hutchison, Stephen
Hui, Jeffrey
Kongtorp, Ruth-Torill
Savji, Nazir
Bussetti, Ana V.
Solovyov, Alexander
Kristoffersen, Anja B.
Celone, Christopher
Street, Craig
Trifonov, Vladimir
Hirschberg, David L.
Rabadan, Raul
Egholm, Michael
Rimstad, Espen
Lipkin, W. Ian
author_facet Palacios, Gustavo
Lovoll, Marie
Tengs, Torstein
Hornig, Mady
Hutchison, Stephen
Hui, Jeffrey
Kongtorp, Ruth-Torill
Savji, Nazir
Bussetti, Ana V.
Solovyov, Alexander
Kristoffersen, Anja B.
Celone, Christopher
Street, Craig
Trifonov, Vladimir
Hirschberg, David L.
Rabadan, Raul
Egholm, Michael
Rimstad, Espen
Lipkin, W. Ian
author_sort Palacios, Gustavo
collection PubMed
description Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fatal disease of farmed Atlantic salmon. First recognized in one farm in Norway in 1999[1], HSMI was subsequently implicated in outbreaks in other farms in Norway and the United Kingdom[2]. Although pathology and disease transmission studies indicated an infectious basis, efforts to identify an agent were unsuccessful. Here we provide evidence that HSMI is associated with infection with piscine reovirus (PRV). PRV is a novel reovirus identified by unbiased high throughput DNA sequencing and a bioinformatics program focused on nucleotide frequency as well as sequence alignment and motif analyses. Formal implication of PRV in HSMI will require isolation in cell culture and fulfillment of Koch's postulates, or prevention or modification of disease through use of specific drugs or vaccines. Nonetheless, as our data indicate that a causal relationship is plausible, measures must be taken to control PRV not only because it threatens domestic salmon production but also due to the potential for transmission to wild salmon populations.
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spelling pubmed-29013332010-07-15 Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus Palacios, Gustavo Lovoll, Marie Tengs, Torstein Hornig, Mady Hutchison, Stephen Hui, Jeffrey Kongtorp, Ruth-Torill Savji, Nazir Bussetti, Ana V. Solovyov, Alexander Kristoffersen, Anja B. Celone, Christopher Street, Craig Trifonov, Vladimir Hirschberg, David L. Rabadan, Raul Egholm, Michael Rimstad, Espen Lipkin, W. Ian PLoS One Research Article Atlantic salmon (Salmo salar L.) mariculture has been associated with epidemics of infectious diseases that threaten not only local production, but also wild fish coming into close proximity to marine pens and fish escaping from them. Heart and skeletal muscle inflammation (HSMI) is a frequently fatal disease of farmed Atlantic salmon. First recognized in one farm in Norway in 1999[1], HSMI was subsequently implicated in outbreaks in other farms in Norway and the United Kingdom[2]. Although pathology and disease transmission studies indicated an infectious basis, efforts to identify an agent were unsuccessful. Here we provide evidence that HSMI is associated with infection with piscine reovirus (PRV). PRV is a novel reovirus identified by unbiased high throughput DNA sequencing and a bioinformatics program focused on nucleotide frequency as well as sequence alignment and motif analyses. Formal implication of PRV in HSMI will require isolation in cell culture and fulfillment of Koch's postulates, or prevention or modification of disease through use of specific drugs or vaccines. Nonetheless, as our data indicate that a causal relationship is plausible, measures must be taken to control PRV not only because it threatens domestic salmon production but also due to the potential for transmission to wild salmon populations. Public Library of Science 2010-07-09 /pmc/articles/PMC2901333/ /pubmed/20634888 http://dx.doi.org/10.1371/journal.pone.0011487 Text en Palacios et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Palacios, Gustavo
Lovoll, Marie
Tengs, Torstein
Hornig, Mady
Hutchison, Stephen
Hui, Jeffrey
Kongtorp, Ruth-Torill
Savji, Nazir
Bussetti, Ana V.
Solovyov, Alexander
Kristoffersen, Anja B.
Celone, Christopher
Street, Craig
Trifonov, Vladimir
Hirschberg, David L.
Rabadan, Raul
Egholm, Michael
Rimstad, Espen
Lipkin, W. Ian
Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus
title Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus
title_full Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus
title_fullStr Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus
title_full_unstemmed Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus
title_short Heart and Skeletal Muscle Inflammation of Farmed Salmon Is Associated with Infection with a Novel Reovirus
title_sort heart and skeletal muscle inflammation of farmed salmon is associated with infection with a novel reovirus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901333/
https://www.ncbi.nlm.nih.gov/pubmed/20634888
http://dx.doi.org/10.1371/journal.pone.0011487
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