Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes

BACKGROUND: To assess the risk of developing Type-1 diabetes among children who were exposed to maternal bereavement during the prenatal or 1-year preconception period. METHODS: We identified N = 1,548,746 singleton births born in Denmark between January 1(st) 1979 through December 31(st) 2004, and...

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Autores principales: Virk, Jasveer, Li, Jiong, Vestergaard, Mogens, Obel, Carsten, Lu, Michael, Olsen, Jørn
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901388/
https://www.ncbi.nlm.nih.gov/pubmed/20634978
http://dx.doi.org/10.1371/journal.pone.0011523
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author Virk, Jasveer
Li, Jiong
Vestergaard, Mogens
Obel, Carsten
Lu, Michael
Olsen, Jørn
author_facet Virk, Jasveer
Li, Jiong
Vestergaard, Mogens
Obel, Carsten
Lu, Michael
Olsen, Jørn
author_sort Virk, Jasveer
collection PubMed
description BACKGROUND: To assess the risk of developing Type-1 diabetes among children who were exposed to maternal bereavement during the prenatal or 1-year preconception period. METHODS: We identified N = 1,548,746 singleton births born in Denmark between January 1(st) 1979 through December 31(st) 2004, and their next of kin. Altogether, 39,857 children were exposed to bereavement during their prenatal life. The main outcome of interest was hospitalization for type-1 diabetes (ICD 8: 249; ICD 10: E10). RESULTS: We found the strongest association for type-1 diabetes among children exposed to traumatic father or sibling deaths (aIRR: 2.03, 1.22–3.38); the association was mainly seen for girls (aIRR: 2.91, 1.61–5.26). CONCLUSIONS: We found evidence to suggest that female fetuses exposed to severe prenatal stress are at increased risk for developing type-1 diabetes.
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spelling pubmed-29013882010-07-15 Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes Virk, Jasveer Li, Jiong Vestergaard, Mogens Obel, Carsten Lu, Michael Olsen, Jørn PLoS One Research Article BACKGROUND: To assess the risk of developing Type-1 diabetes among children who were exposed to maternal bereavement during the prenatal or 1-year preconception period. METHODS: We identified N = 1,548,746 singleton births born in Denmark between January 1(st) 1979 through December 31(st) 2004, and their next of kin. Altogether, 39,857 children were exposed to bereavement during their prenatal life. The main outcome of interest was hospitalization for type-1 diabetes (ICD 8: 249; ICD 10: E10). RESULTS: We found the strongest association for type-1 diabetes among children exposed to traumatic father or sibling deaths (aIRR: 2.03, 1.22–3.38); the association was mainly seen for girls (aIRR: 2.91, 1.61–5.26). CONCLUSIONS: We found evidence to suggest that female fetuses exposed to severe prenatal stress are at increased risk for developing type-1 diabetes. Public Library of Science 2010-07-09 /pmc/articles/PMC2901388/ /pubmed/20634978 http://dx.doi.org/10.1371/journal.pone.0011523 Text en Virk et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Virk, Jasveer
Li, Jiong
Vestergaard, Mogens
Obel, Carsten
Lu, Michael
Olsen, Jørn
Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes
title Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes
title_full Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes
title_fullStr Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes
title_full_unstemmed Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes
title_short Early Life Disease Programming during the Preconception and Prenatal Period: Making the Link between Stressful Life Events and Type-1 Diabetes
title_sort early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901388/
https://www.ncbi.nlm.nih.gov/pubmed/20634978
http://dx.doi.org/10.1371/journal.pone.0011523
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