Cargando…

In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance

BACKGROUND: Multilumen catheters are commonly used in critically ill children. Their use, however, is associated with significant morbidity. We studied the simultaneous administration of incompatible drugs using a new triple-lumen catheter with decreased length and port to port distances. METHODS: T...

Descripción completa

Detalles Bibliográficos
Autores principales: Reyes, Gerardo, Mander, Gurpreet S, Husayni, Tarek S, Sulayman, Rabi F, Jaimovich, David G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29014/
https://www.ncbi.nlm.nih.gov/pubmed/11056724
_version_ 1782119945414377472
author Reyes, Gerardo
Mander, Gurpreet S
Husayni, Tarek S
Sulayman, Rabi F
Jaimovich, David G
author_facet Reyes, Gerardo
Mander, Gurpreet S
Husayni, Tarek S
Sulayman, Rabi F
Jaimovich, David G
author_sort Reyes, Gerardo
collection PubMed
description BACKGROUND: Multilumen catheters are commonly used in critically ill children. Their use, however, is associated with significant morbidity. We studied the simultaneous administration of incompatible drugs using a new triple-lumen catheter with decreased length and port to port distances. METHODS: Ten domestic swine, 10–20 kg in weight, were divided into two groups of five. Total parenteral nutrition was administered through the distal port and phenytoin was administered as a bolus and as an infusion in each group. Samples were taken from two sites during the bolus and at 1, 5, and 15 min during phenytoin infusion. Histograms were generated for particle size and concentration. Samples were also examined under the microscope for particles. RESULTS: Histograms of particle size did not show any alteration of the histogram that would suggest particle size > 2 μm in diameter in the study or control samples. No particles were identified by phase microscope, light microscope, or Wright stain smear. CONCLUSIONS: The use of a triple-lumen catheter with a distance of 0.4cm between the proximal port and the medial port and 1.3 cm between the medial port and the distal port, for the in vivo simultaneous administration of incompatible solutions does not result in precipitates large enough to cause adverse clinical effects.
format Text
id pubmed-29014
institution National Center for Biotechnology Information
language English
publishDate 1999
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-290142001-03-22 In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance Reyes, Gerardo Mander, Gurpreet S Husayni, Tarek S Sulayman, Rabi F Jaimovich, David G Crit Care Research Paper BACKGROUND: Multilumen catheters are commonly used in critically ill children. Their use, however, is associated with significant morbidity. We studied the simultaneous administration of incompatible drugs using a new triple-lumen catheter with decreased length and port to port distances. METHODS: Ten domestic swine, 10–20 kg in weight, were divided into two groups of five. Total parenteral nutrition was administered through the distal port and phenytoin was administered as a bolus and as an infusion in each group. Samples were taken from two sites during the bolus and at 1, 5, and 15 min during phenytoin infusion. Histograms were generated for particle size and concentration. Samples were also examined under the microscope for particles. RESULTS: Histograms of particle size did not show any alteration of the histogram that would suggest particle size > 2 μm in diameter in the study or control samples. No particles were identified by phase microscope, light microscope, or Wright stain smear. CONCLUSIONS: The use of a triple-lumen catheter with a distance of 0.4cm between the proximal port and the medial port and 1.3 cm between the medial port and the distal port, for the in vivo simultaneous administration of incompatible solutions does not result in precipitates large enough to cause adverse clinical effects. BioMed Central 1999 1999-03-19 /pmc/articles/PMC29014/ /pubmed/11056724 Text en Copyright © 1999 Current Science Ltd
spellingShingle Research Paper
Reyes, Gerardo
Mander, Gurpreet S
Husayni, Tarek S
Sulayman, Rabi F
Jaimovich, David G
In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance
title In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance
title_full In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance
title_fullStr In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance
title_full_unstemmed In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance
title_short In-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance
title_sort in-vivo evaluation of simultaneous administration of incompatible drugs in a central venous catheter with a decreased port to port distance
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29014/
https://www.ncbi.nlm.nih.gov/pubmed/11056724
work_keys_str_mv AT reyesgerardo invivoevaluationofsimultaneousadministrationofincompatibledrugsinacentralvenouscatheterwithadecreasedporttoportdistance
AT mandergurpreets invivoevaluationofsimultaneousadministrationofincompatibledrugsinacentralvenouscatheterwithadecreasedporttoportdistance
AT husaynitareks invivoevaluationofsimultaneousadministrationofincompatibledrugsinacentralvenouscatheterwithadecreasedporttoportdistance
AT sulaymanrabif invivoevaluationofsimultaneousadministrationofincompatibledrugsinacentralvenouscatheterwithadecreasedporttoportdistance
AT jaimovichdavidg invivoevaluationofsimultaneousadministrationofincompatibledrugsinacentralvenouscatheterwithadecreasedporttoportdistance