Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine

Novel ruthenium(III) complexes with histamine [RuCl(4)(dmso-S)(histamineH)] · H((2))O (1a) and [RuCl(4)(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand w...

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Detalles Bibliográficos
Autores principales: Kljun, Jakob, Petriček, Saša, Žigon, Dušan, Hudej, Rosana, Miklavčič, Damijan, Turel, Iztok
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901621/
https://www.ncbi.nlm.nih.gov/pubmed/20631838
http://dx.doi.org/10.1155/2010/183097
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author Kljun, Jakob
Petriček, Saša
Žigon, Dušan
Hudej, Rosana
Miklavčič, Damijan
Turel, Iztok
author_facet Kljun, Jakob
Petriček, Saša
Žigon, Dušan
Hudej, Rosana
Miklavčič, Damijan
Turel, Iztok
author_sort Kljun, Jakob
collection PubMed
description Novel ruthenium(III) complexes with histamine [RuCl(4)(dmso-S)(histamineH)] · H((2))O (1a) and [RuCl(4)(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment.
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spelling pubmed-29016212010-07-14 Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine Kljun, Jakob Petriček, Saša Žigon, Dušan Hudej, Rosana Miklavčič, Damijan Turel, Iztok Bioinorg Chem Appl Research Article Novel ruthenium(III) complexes with histamine [RuCl(4)(dmso-S)(histamineH)] · H((2))O (1a) and [RuCl(4)(dmso-S)(histamineH)] (1b) have been prepared and characterized by X-ray structure analysis. Their crystal structures are similar and show a protonated amino group on the side chain of the ligand which is not very common for a simple heterocyclic derivative such as histamine. Biological assays to test the cytotoxicity of the compound 1b combined with electroporation were performed to determine its potential for future medical applications in cancer treatment. Hindawi Publishing Corporation 2010 2010-06-02 /pmc/articles/PMC2901621/ /pubmed/20631838 http://dx.doi.org/10.1155/2010/183097 Text en Copyright © 2010 Jakob Kljun et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kljun, Jakob
Petriček, Saša
Žigon, Dušan
Hudej, Rosana
Miklavčič, Damijan
Turel, Iztok
Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine
title Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine
title_full Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine
title_fullStr Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine
title_full_unstemmed Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine
title_short Synthesis and Characterization of Novel Ruthenium(III) Complexes with Histamine
title_sort synthesis and characterization of novel ruthenium(iii) complexes with histamine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901621/
https://www.ncbi.nlm.nih.gov/pubmed/20631838
http://dx.doi.org/10.1155/2010/183097
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