A Plausible Role for the Presence of Internal Shine-Dalgarno Sites

The presence of nucleotide hybridization between the 3′ end of 16S rRNA and mRNA sequence upstream of the start codon is well known in bacteria. In this paper, we detect the presence of such hybridization sites inside the coding regions of E. coli genes, and analyze their proximity to clusters of sl...

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Detalles Bibliográficos
Autor principal: Ponnala, Lalit
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2010
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901628/
https://www.ncbi.nlm.nih.gov/pubmed/20634982
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author Ponnala, Lalit
author_facet Ponnala, Lalit
author_sort Ponnala, Lalit
collection PubMed
description The presence of nucleotide hybridization between the 3′ end of 16S rRNA and mRNA sequence upstream of the start codon is well known in bacteria. In this paper, we detect the presence of such hybridization sites inside the coding regions of E. coli genes, and analyze their proximity to clusters of slow-translating codons. We study this phenomenon in genes of high and low expression separately. Based on our findings, we propose an explanation for the presence of RNA hybridization within the translated regions of bacterial genes.
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spelling pubmed-29016282010-07-15 A Plausible Role for the Presence of Internal Shine-Dalgarno Sites Ponnala, Lalit Bioinform Biol Insights Original Research The presence of nucleotide hybridization between the 3′ end of 16S rRNA and mRNA sequence upstream of the start codon is well known in bacteria. In this paper, we detect the presence of such hybridization sites inside the coding regions of E. coli genes, and analyze their proximity to clusters of slow-translating codons. We study this phenomenon in genes of high and low expression separately. Based on our findings, we propose an explanation for the presence of RNA hybridization within the translated regions of bacterial genes. Libertas Academica 2010-06-28 /pmc/articles/PMC2901628/ /pubmed/20634982 Text en © 2010 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Original Research
Ponnala, Lalit
A Plausible Role for the Presence of Internal Shine-Dalgarno Sites
title A Plausible Role for the Presence of Internal Shine-Dalgarno Sites
title_full A Plausible Role for the Presence of Internal Shine-Dalgarno Sites
title_fullStr A Plausible Role for the Presence of Internal Shine-Dalgarno Sites
title_full_unstemmed A Plausible Role for the Presence of Internal Shine-Dalgarno Sites
title_short A Plausible Role for the Presence of Internal Shine-Dalgarno Sites
title_sort plausible role for the presence of internal shine-dalgarno sites
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901628/
https://www.ncbi.nlm.nih.gov/pubmed/20634982
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