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Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats

Recent studies have indicated that heat shock proteins (HSPs), which function as molecular chaperones, play important roles in cellular responses to stress-related events. However, the gender difference in the expression of HSP in the gastric mucosa remains unclear. In order to understand the mechan...

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Autores principales: Takahashi, Taiji, Otaka, Michiro, Odashima, Masaru, Tamaki, Kumiko, Takada, Makiko, Izumi, Yuko, Shibuya, Tomoyoshi, Sakamoto, Naoto, Itoh, Hideaki, Watanabe, Sumio
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901766/
https://www.ncbi.nlm.nih.gov/pubmed/20664733
http://dx.doi.org/10.3164/jcbn.10-32
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author Takahashi, Taiji
Otaka, Michiro
Odashima, Masaru
Tamaki, Kumiko
Takada, Makiko
Izumi, Yuko
Shibuya, Tomoyoshi
Sakamoto, Naoto
Itoh, Hideaki
Watanabe, Sumio
author_facet Takahashi, Taiji
Otaka, Michiro
Odashima, Masaru
Tamaki, Kumiko
Takada, Makiko
Izumi, Yuko
Shibuya, Tomoyoshi
Sakamoto, Naoto
Itoh, Hideaki
Watanabe, Sumio
author_sort Takahashi, Taiji
collection PubMed
description Recent studies have indicated that heat shock proteins (HSPs), which function as molecular chaperones, play important roles in cellular responses to stress-related events. However, the gender difference in the expression of HSP in the gastric mucosa remains unclear. In order to understand the mechanism of gender difference in the prevalence or severity of gastric mucosal lesions, the expression level of HSP and the correlation of estrogen to HSP induction in the gastric mucosa were evaluated in this study. The basal expression levels of HSP60 and HSP90 in the gastric mucosa were significantly higher in females than those in males. The gastric ulcer index was significantly higher in male rats compared to female rats observed after 12 h water immersion stress exposure. At this time point, the expression levels of HSP60 and HSP90 in the gastric mucosa were significantly higher in females than those in males. An estrogen-treatment significantly induced the expression of HSP60, HSP70 and HSP90 in the gastric mucosa. Inversely, an ovariectomy dramatically reduced the expression of HSP60, HSP70 and HSP90 in the gastric mucosa. Our results suggested that estrogen might play an important role in gastric mucosal protection with the induction of gastric mucosal HSPs.
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spelling pubmed-29017662010-07-27 Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats Takahashi, Taiji Otaka, Michiro Odashima, Masaru Tamaki, Kumiko Takada, Makiko Izumi, Yuko Shibuya, Tomoyoshi Sakamoto, Naoto Itoh, Hideaki Watanabe, Sumio J Clin Biochem Nutr Original Article Recent studies have indicated that heat shock proteins (HSPs), which function as molecular chaperones, play important roles in cellular responses to stress-related events. However, the gender difference in the expression of HSP in the gastric mucosa remains unclear. In order to understand the mechanism of gender difference in the prevalence or severity of gastric mucosal lesions, the expression level of HSP and the correlation of estrogen to HSP induction in the gastric mucosa were evaluated in this study. The basal expression levels of HSP60 and HSP90 in the gastric mucosa were significantly higher in females than those in males. The gastric ulcer index was significantly higher in male rats compared to female rats observed after 12 h water immersion stress exposure. At this time point, the expression levels of HSP60 and HSP90 in the gastric mucosa were significantly higher in females than those in males. An estrogen-treatment significantly induced the expression of HSP60, HSP70 and HSP90 in the gastric mucosa. Inversely, an ovariectomy dramatically reduced the expression of HSP60, HSP70 and HSP90 in the gastric mucosa. Our results suggested that estrogen might play an important role in gastric mucosal protection with the induction of gastric mucosal HSPs. the Society for Free Radical Research Japan 2010-07 2010-05-26 /pmc/articles/PMC2901766/ /pubmed/20664733 http://dx.doi.org/10.3164/jcbn.10-32 Text en Copyright © 2010 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Takahashi, Taiji
Otaka, Michiro
Odashima, Masaru
Tamaki, Kumiko
Takada, Makiko
Izumi, Yuko
Shibuya, Tomoyoshi
Sakamoto, Naoto
Itoh, Hideaki
Watanabe, Sumio
Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats
title Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats
title_full Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats
title_fullStr Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats
title_full_unstemmed Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats
title_short Correlation of Heat Shock Protein Expression to Gender Difference in Development of Stress-Induced Gastric Mucosal Injury in Rats
title_sort correlation of heat shock protein expression to gender difference in development of stress-induced gastric mucosal injury in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901766/
https://www.ncbi.nlm.nih.gov/pubmed/20664733
http://dx.doi.org/10.3164/jcbn.10-32
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