Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay

Three new minor components, the pyridoacridine alkaloids 1-hydroxy-deoxyamphimedine (1), 3-hydroxy-deoxyamphimedine (2), debromopetrosamine (3), and three known compounds, amphimedine (4), neoamphimedine (5) and deoxyamphimedine (6), have been isolated from the sponge Xestospongia cf. carbonaria, co...

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Autores principales: Wei, Xiaomei, Bugni, Tim S., Harper, Mary Kay, Sandoval, Imelda T., Manos, Elizabeth J., Swift, Jennifer, Van Wagoner, Ryan M., Jones, David A., Ireland, Chris M.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901824/
https://www.ncbi.nlm.nih.gov/pubmed/20631869
http://dx.doi.org/10.3390/md8061769
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author Wei, Xiaomei
Bugni, Tim S.
Harper, Mary Kay
Sandoval, Imelda T.
Manos, Elizabeth J.
Swift, Jennifer
Van Wagoner, Ryan M.
Jones, David A.
Ireland, Chris M.
author_facet Wei, Xiaomei
Bugni, Tim S.
Harper, Mary Kay
Sandoval, Imelda T.
Manos, Elizabeth J.
Swift, Jennifer
Van Wagoner, Ryan M.
Jones, David A.
Ireland, Chris M.
author_sort Wei, Xiaomei
collection PubMed
description Three new minor components, the pyridoacridine alkaloids 1-hydroxy-deoxyamphimedine (1), 3-hydroxy-deoxyamphimedine (2), debromopetrosamine (3), and three known compounds, amphimedine (4), neoamphimedine (5) and deoxyamphimedine (6), have been isolated from the sponge Xestospongia cf. carbonaria, collected in Palau. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1–6 were evaluated in a zebrafish phenotype-based assay. Amphimedine (4) was the only compound that caused a phenotype in zebrafish embryos at 30 μM. No phenotype other than death was observed for compounds 1–3, 5, 6.
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spelling pubmed-29018242010-07-14 Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay Wei, Xiaomei Bugni, Tim S. Harper, Mary Kay Sandoval, Imelda T. Manos, Elizabeth J. Swift, Jennifer Van Wagoner, Ryan M. Jones, David A. Ireland, Chris M. Mar Drugs Article Three new minor components, the pyridoacridine alkaloids 1-hydroxy-deoxyamphimedine (1), 3-hydroxy-deoxyamphimedine (2), debromopetrosamine (3), and three known compounds, amphimedine (4), neoamphimedine (5) and deoxyamphimedine (6), have been isolated from the sponge Xestospongia cf. carbonaria, collected in Palau. Structures were assigned on the basis of extensive 1D and 2D NMR studies as well as analysis by HRESIMS. Compounds 1–6 were evaluated in a zebrafish phenotype-based assay. Amphimedine (4) was the only compound that caused a phenotype in zebrafish embryos at 30 μM. No phenotype other than death was observed for compounds 1–3, 5, 6. Molecular Diversity Preservation International 2010-06-02 /pmc/articles/PMC2901824/ /pubmed/20631869 http://dx.doi.org/10.3390/md8061769 Text en © 2008 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Wei, Xiaomei
Bugni, Tim S.
Harper, Mary Kay
Sandoval, Imelda T.
Manos, Elizabeth J.
Swift, Jennifer
Van Wagoner, Ryan M.
Jones, David A.
Ireland, Chris M.
Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay
title Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay
title_full Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay
title_fullStr Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay
title_full_unstemmed Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay
title_short Evaluation of Pyridoacridine Alkaloids in a Zebrafish Phenotypic Assay
title_sort evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901824/
https://www.ncbi.nlm.nih.gov/pubmed/20631869
http://dx.doi.org/10.3390/md8061769
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