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B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease
Nonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus en...
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901951/ https://www.ncbi.nlm.nih.gov/pubmed/12603998 http://dx.doi.org/10.3201/eid0902.020272 |
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author | Huff, Jennifer L. Barry, Peter A. |
author_facet | Huff, Jennifer L. Barry, Peter A. |
author_sort | Huff, Jennifer L. |
collection | PubMed |
description | Nonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus endemic in Asian macaques, is closely related to herpes simplex virus (HSV). Most macaques carry B virus without overt signs of disease. However, zoonotic infection with B virus in humans usually results in fatal encephalomyelitis or severe neurologic impairment. Although the incidence of human infection with B virus is low, a death rate of >70% before the availability of antiviral therapy makes this virus a serious zoonotic threat. Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death. |
format | Text |
id | pubmed-2901951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-29019512010-07-15 B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease Huff, Jennifer L. Barry, Peter A. Emerg Infect Dis Synopsis Nonhuman primates are widely used in biomedical research because of their genetic, anatomic, and physiologic similarities to humans. In this setting, human contact directly with macaques or with their tissues and fluids sometimes occurs. Cercopithecine herpesvirus 1 (B virus), an alphaherpesvirus endemic in Asian macaques, is closely related to herpes simplex virus (HSV). Most macaques carry B virus without overt signs of disease. However, zoonotic infection with B virus in humans usually results in fatal encephalomyelitis or severe neurologic impairment. Although the incidence of human infection with B virus is low, a death rate of >70% before the availability of antiviral therapy makes this virus a serious zoonotic threat. Knowledge of the clinical signs and risk factors for human B-virus disease allows early initiation of antiviral therapy and prevents severe disease or death. Centers for Disease Control and Prevention 2003-02 /pmc/articles/PMC2901951/ /pubmed/12603998 http://dx.doi.org/10.3201/eid0902.020272 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Synopsis Huff, Jennifer L. Barry, Peter A. B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
title | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
title_full | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
title_fullStr | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
title_full_unstemmed | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
title_short | B-Virus (Cercopithecine herpesvirus 1) Infection in Humans and Macaques: Potential for Zoonotic Disease |
title_sort | b-virus (cercopithecine herpesvirus 1) infection in humans and macaques: potential for zoonotic disease |
topic | Synopsis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901951/ https://www.ncbi.nlm.nih.gov/pubmed/12603998 http://dx.doi.org/10.3201/eid0902.020272 |
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