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Crosstalk between Iron Metabolism and Erythropoiesis

Iron metabolism and erythropoiesis are inextricably linked. The majority of iron extracted from circulation daily is used for hemoglobin synthesis. In the last 15 years, major advances have been made in understanding the pathways regulating iron metabolism. Hepcidin is a key regulator of iron absorp...

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Detalles Bibliográficos
Autores principales: Li, Huihui, Ginzburg, Yelena Z.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902017/
https://www.ncbi.nlm.nih.gov/pubmed/20631898
http://dx.doi.org/10.1155/2010/605435
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author Li, Huihui
Ginzburg, Yelena Z.
author_facet Li, Huihui
Ginzburg, Yelena Z.
author_sort Li, Huihui
collection PubMed
description Iron metabolism and erythropoiesis are inextricably linked. The majority of iron extracted from circulation daily is used for hemoglobin synthesis. In the last 15 years, major advances have been made in understanding the pathways regulating iron metabolism. Hepcidin is a key regulator of iron absorption and recycling and is itself regulated by erythropoiesis. While several viable candidates have been proposed, elucidating the “erythroid regulator” of hepcidin continues to generate significant experimental activity in the field. Although the mechanism responsible for sensing iron demand for erythropoiesis is still incompletely understood, evaluating diseases in which disordered erythropoiesis and/or iron metabolism are showcased has resulted in a more robust appreciation of potential candidates coordinated erythroid iron demand with regulators of iron supply. We present data drawn from four different conditions—iron deficiency, congenital hypotransferrinemia, beta-thalassemia, and hereditary hemochromatosis—both in human and non-human models of disease, together suggesting that erythroid iron demand exerts a stronger influence on circulating iron supply than systemic iron stores. Greater understanding of the interplay between the key factors involved in the regulation of iron metabolism and erythropoiesis will help develop more effective therapies for disorders of iron overload, iron deficiency, and hemoglobin synthesis.
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spelling pubmed-29020172010-07-14 Crosstalk between Iron Metabolism and Erythropoiesis Li, Huihui Ginzburg, Yelena Z. Adv Hematol Review Article Iron metabolism and erythropoiesis are inextricably linked. The majority of iron extracted from circulation daily is used for hemoglobin synthesis. In the last 15 years, major advances have been made in understanding the pathways regulating iron metabolism. Hepcidin is a key regulator of iron absorption and recycling and is itself regulated by erythropoiesis. While several viable candidates have been proposed, elucidating the “erythroid regulator” of hepcidin continues to generate significant experimental activity in the field. Although the mechanism responsible for sensing iron demand for erythropoiesis is still incompletely understood, evaluating diseases in which disordered erythropoiesis and/or iron metabolism are showcased has resulted in a more robust appreciation of potential candidates coordinated erythroid iron demand with regulators of iron supply. We present data drawn from four different conditions—iron deficiency, congenital hypotransferrinemia, beta-thalassemia, and hereditary hemochromatosis—both in human and non-human models of disease, together suggesting that erythroid iron demand exerts a stronger influence on circulating iron supply than systemic iron stores. Greater understanding of the interplay between the key factors involved in the regulation of iron metabolism and erythropoiesis will help develop more effective therapies for disorders of iron overload, iron deficiency, and hemoglobin synthesis. Hindawi Publishing Corporation 2010 2010-06-10 /pmc/articles/PMC2902017/ /pubmed/20631898 http://dx.doi.org/10.1155/2010/605435 Text en Copyright © 2010 H. Li and Y. Z. Ginzburg. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Huihui
Ginzburg, Yelena Z.
Crosstalk between Iron Metabolism and Erythropoiesis
title Crosstalk between Iron Metabolism and Erythropoiesis
title_full Crosstalk between Iron Metabolism and Erythropoiesis
title_fullStr Crosstalk between Iron Metabolism and Erythropoiesis
title_full_unstemmed Crosstalk between Iron Metabolism and Erythropoiesis
title_short Crosstalk between Iron Metabolism and Erythropoiesis
title_sort crosstalk between iron metabolism and erythropoiesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902017/
https://www.ncbi.nlm.nih.gov/pubmed/20631898
http://dx.doi.org/10.1155/2010/605435
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