Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs

We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls....

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Detalles Bibliográficos
Autores principales: Ahmadi, Neda, Goldman, Radoslav, Seillier-Moiseiwitsch, Françoise, Noone, Anne-Michelle, Kosti, Ourania, Davidson, Bruce J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902018/
https://www.ncbi.nlm.nih.gov/pubmed/20628564
http://dx.doi.org/10.1155/2010/424161
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author Ahmadi, Neda
Goldman, Radoslav
Seillier-Moiseiwitsch, Françoise
Noone, Anne-Michelle
Kosti, Ourania
Davidson, Bruce J.
author_facet Ahmadi, Neda
Goldman, Radoslav
Seillier-Moiseiwitsch, Françoise
Noone, Anne-Michelle
Kosti, Ourania
Davidson, Bruce J.
author_sort Ahmadi, Neda
collection PubMed
description We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users.
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spelling pubmed-29020182010-07-13 Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs Ahmadi, Neda Goldman, Radoslav Seillier-Moiseiwitsch, Françoise Noone, Anne-Michelle Kosti, Ourania Davidson, Bruce J. Int J Otolaryngol Research Article We evaluated the chemopreventive effect of nonsteroidal anti-inflammatory drug (NSAID) use in head and neck squamous cell carcinomas (HNSCC) by conducting a case-control study based on the administration of a standardized questionnaire to 71 incident HNSCC cases and same number of healthy controls. NSAID use was associated with a 75% reduction in risk of developing HNSCC. A significant risk reduction was noted in association with frequency of NSAID use. Restricting the analysis to aspirin users revealed a significant 90% reduction in risk of developing HNSCC. This study provides evidence for a significant reduction in the risk of developing HNSCC in users of NSAIDs, and specifically aspirin users. Hindawi Publishing Corporation 2010 2010-06-03 /pmc/articles/PMC2902018/ /pubmed/20628564 http://dx.doi.org/10.1155/2010/424161 Text en Copyright © 2010 Neda Ahmadi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ahmadi, Neda
Goldman, Radoslav
Seillier-Moiseiwitsch, Françoise
Noone, Anne-Michelle
Kosti, Ourania
Davidson, Bruce J.
Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs
title Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs
title_full Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs
title_fullStr Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs
title_full_unstemmed Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs
title_short Decreased Risk of Squamous Cell Carcinoma of the Head and Neck in Users of Nonsteroidal Anti-Inflammatory Drugs
title_sort decreased risk of squamous cell carcinoma of the head and neck in users of nonsteroidal anti-inflammatory drugs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902018/
https://www.ncbi.nlm.nih.gov/pubmed/20628564
http://dx.doi.org/10.1155/2010/424161
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