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Cognitive deficits in children of alcoholics: At risk before the first sip!

BACKGROUND: High family loading for alcoholism, early onset of alcohol use and childhood disinhibitory behaviors, persisting into adulthood, increase the susceptibility to alcoholism. At the psychophysiology level, reduced amplitude of the P300 component of the Evoked Response Potential is associate...

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Autores principales: Silva, Melvin Chagas, Benegal, Vivek, Devi, Manjula, Mukundan, C. R.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902091/
https://www.ncbi.nlm.nih.gov/pubmed/20661384
http://dx.doi.org/10.4103/0019-5545.37319
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author Silva, Melvin Chagas
Benegal, Vivek
Devi, Manjula
Mukundan, C. R.
author_facet Silva, Melvin Chagas
Benegal, Vivek
Devi, Manjula
Mukundan, C. R.
author_sort Silva, Melvin Chagas
collection PubMed
description BACKGROUND: High family loading for alcoholism, early onset of alcohol use and childhood disinhibitory behaviors, persisting into adulthood, increase the susceptibility to alcoholism. At the psychophysiology level, reduced amplitude of the P300 component of the Evoked Response Potential is associated with externalizing psychopathology in children. Children of alcoholics have reduced P300 amplitudes. Preliminary data suggests a developmental lag phenomenon in the maturation of the P300. AIMS: The study compares the amplitude and topography of the P300 generated in response to a visual task, between subjects at high risk (HR) and those at low risk (LR) for alcoholism and its relation to externalizing behaviors. RESULTS: HR subjects have lower P300 amplitudes over frontal brain areas. Differences are greater in young, tending to converge with increasing age. There is a strong association between this reduced brain activation and an excess of externalizing behaviors in HR individuals. CONCLUSION: A maturational lag in brain development causing central nervous system disinhibition and externalizing behaviors may underlie the susceptibility to alcoholism.
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spelling pubmed-29020912010-07-26 Cognitive deficits in children of alcoholics: At risk before the first sip! Silva, Melvin Chagas Benegal, Vivek Devi, Manjula Mukundan, C. R. Indian J Psychiatry Original Article BACKGROUND: High family loading for alcoholism, early onset of alcohol use and childhood disinhibitory behaviors, persisting into adulthood, increase the susceptibility to alcoholism. At the psychophysiology level, reduced amplitude of the P300 component of the Evoked Response Potential is associated with externalizing psychopathology in children. Children of alcoholics have reduced P300 amplitudes. Preliminary data suggests a developmental lag phenomenon in the maturation of the P300. AIMS: The study compares the amplitude and topography of the P300 generated in response to a visual task, between subjects at high risk (HR) and those at low risk (LR) for alcoholism and its relation to externalizing behaviors. RESULTS: HR subjects have lower P300 amplitudes over frontal brain areas. Differences are greater in young, tending to converge with increasing age. There is a strong association between this reduced brain activation and an excess of externalizing behaviors in HR individuals. CONCLUSION: A maturational lag in brain development causing central nervous system disinhibition and externalizing behaviors may underlie the susceptibility to alcoholism. Medknow Publications 2007 /pmc/articles/PMC2902091/ /pubmed/20661384 http://dx.doi.org/10.4103/0019-5545.37319 Text en © Indian Journal of Psychiatry http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Silva, Melvin Chagas
Benegal, Vivek
Devi, Manjula
Mukundan, C. R.
Cognitive deficits in children of alcoholics: At risk before the first sip!
title Cognitive deficits in children of alcoholics: At risk before the first sip!
title_full Cognitive deficits in children of alcoholics: At risk before the first sip!
title_fullStr Cognitive deficits in children of alcoholics: At risk before the first sip!
title_full_unstemmed Cognitive deficits in children of alcoholics: At risk before the first sip!
title_short Cognitive deficits in children of alcoholics: At risk before the first sip!
title_sort cognitive deficits in children of alcoholics: at risk before the first sip!
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902091/
https://www.ncbi.nlm.nih.gov/pubmed/20661384
http://dx.doi.org/10.4103/0019-5545.37319
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