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Cognitive deficits in children of alcoholics: At risk before the first sip!
BACKGROUND: High family loading for alcoholism, early onset of alcohol use and childhood disinhibitory behaviors, persisting into adulthood, increase the susceptibility to alcoholism. At the psychophysiology level, reduced amplitude of the P300 component of the Evoked Response Potential is associate...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902091/ https://www.ncbi.nlm.nih.gov/pubmed/20661384 http://dx.doi.org/10.4103/0019-5545.37319 |
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author | Silva, Melvin Chagas Benegal, Vivek Devi, Manjula Mukundan, C. R. |
author_facet | Silva, Melvin Chagas Benegal, Vivek Devi, Manjula Mukundan, C. R. |
author_sort | Silva, Melvin Chagas |
collection | PubMed |
description | BACKGROUND: High family loading for alcoholism, early onset of alcohol use and childhood disinhibitory behaviors, persisting into adulthood, increase the susceptibility to alcoholism. At the psychophysiology level, reduced amplitude of the P300 component of the Evoked Response Potential is associated with externalizing psychopathology in children. Children of alcoholics have reduced P300 amplitudes. Preliminary data suggests a developmental lag phenomenon in the maturation of the P300. AIMS: The study compares the amplitude and topography of the P300 generated in response to a visual task, between subjects at high risk (HR) and those at low risk (LR) for alcoholism and its relation to externalizing behaviors. RESULTS: HR subjects have lower P300 amplitudes over frontal brain areas. Differences are greater in young, tending to converge with increasing age. There is a strong association between this reduced brain activation and an excess of externalizing behaviors in HR individuals. CONCLUSION: A maturational lag in brain development causing central nervous system disinhibition and externalizing behaviors may underlie the susceptibility to alcoholism. |
format | Text |
id | pubmed-2902091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29020912010-07-26 Cognitive deficits in children of alcoholics: At risk before the first sip! Silva, Melvin Chagas Benegal, Vivek Devi, Manjula Mukundan, C. R. Indian J Psychiatry Original Article BACKGROUND: High family loading for alcoholism, early onset of alcohol use and childhood disinhibitory behaviors, persisting into adulthood, increase the susceptibility to alcoholism. At the psychophysiology level, reduced amplitude of the P300 component of the Evoked Response Potential is associated with externalizing psychopathology in children. Children of alcoholics have reduced P300 amplitudes. Preliminary data suggests a developmental lag phenomenon in the maturation of the P300. AIMS: The study compares the amplitude and topography of the P300 generated in response to a visual task, between subjects at high risk (HR) and those at low risk (LR) for alcoholism and its relation to externalizing behaviors. RESULTS: HR subjects have lower P300 amplitudes over frontal brain areas. Differences are greater in young, tending to converge with increasing age. There is a strong association between this reduced brain activation and an excess of externalizing behaviors in HR individuals. CONCLUSION: A maturational lag in brain development causing central nervous system disinhibition and externalizing behaviors may underlie the susceptibility to alcoholism. Medknow Publications 2007 /pmc/articles/PMC2902091/ /pubmed/20661384 http://dx.doi.org/10.4103/0019-5545.37319 Text en © Indian Journal of Psychiatry http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Silva, Melvin Chagas Benegal, Vivek Devi, Manjula Mukundan, C. R. Cognitive deficits in children of alcoholics: At risk before the first sip! |
title | Cognitive deficits in children of alcoholics: At risk before the first sip! |
title_full | Cognitive deficits in children of alcoholics: At risk before the first sip! |
title_fullStr | Cognitive deficits in children of alcoholics: At risk before the first sip! |
title_full_unstemmed | Cognitive deficits in children of alcoholics: At risk before the first sip! |
title_short | Cognitive deficits in children of alcoholics: At risk before the first sip! |
title_sort | cognitive deficits in children of alcoholics: at risk before the first sip! |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902091/ https://www.ncbi.nlm.nih.gov/pubmed/20661384 http://dx.doi.org/10.4103/0019-5545.37319 |
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