Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?

Animal mammary glands have been successfully employed to produce therapeutic recombinant human proteins. However, considerable variation in animal mammary transgene expression efficiency has been reported. We now consider whether aspects of codon usage and/or protein tertiary structure underlie this...

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Detalles Bibliográficos
Autores principales: He, Zuyong, Zhao, Yiqiang, Mei, Gui, Li, Ning, Chen, Yaosheng
Formato: Texto
Lenguaje:English
Publicado: Springer Netherlands 2010
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902731/
https://www.ncbi.nlm.nih.gov/pubmed/20563642
http://dx.doi.org/10.1007/s11248-010-9411-8
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author He, Zuyong
Zhao, Yiqiang
Mei, Gui
Li, Ning
Chen, Yaosheng
author_facet He, Zuyong
Zhao, Yiqiang
Mei, Gui
Li, Ning
Chen, Yaosheng
author_sort He, Zuyong
collection PubMed
description Animal mammary glands have been successfully employed to produce therapeutic recombinant human proteins. However, considerable variation in animal mammary transgene expression efficiency has been reported. We now consider whether aspects of codon usage and/or protein tertiary structure underlie this variation in mammary transgene expression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11248-010-9411-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-29027312010-08-06 Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage? He, Zuyong Zhao, Yiqiang Mei, Gui Li, Ning Chen, Yaosheng Transgenic Res Perspective Animal mammary glands have been successfully employed to produce therapeutic recombinant human proteins. However, considerable variation in animal mammary transgene expression efficiency has been reported. We now consider whether aspects of codon usage and/or protein tertiary structure underlie this variation in mammary transgene expression. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11248-010-9411-8) contains supplementary material, which is available to authorized users. Springer Netherlands 2010-06-19 2010 /pmc/articles/PMC2902731/ /pubmed/20563642 http://dx.doi.org/10.1007/s11248-010-9411-8 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Perspective
He, Zuyong
Zhao, Yiqiang
Mei, Gui
Li, Ning
Chen, Yaosheng
Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
title Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
title_full Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
title_fullStr Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
title_full_unstemmed Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
title_short Could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
title_sort could protein tertiary structure influence mammary transgene expression more than tissue specific codon usage?
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902731/
https://www.ncbi.nlm.nih.gov/pubmed/20563642
http://dx.doi.org/10.1007/s11248-010-9411-8
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