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Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases

Type I collagen cleavage is crucial for tissue remodeling, but its homotrimeric isoform is resistant to all collagenases. The homotrimers occur in fetal tissues, fibrosis, and cancer, where their collagenase resistance may play an important physiological role. To understand the mechanism of this res...

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Detalles Bibliográficos
Autores principales:	Han, Sejin, Makareeva, Elena, Kuznetsova, Natalia V., DeRidder, Angela M., Sutter, Mary Beth, Losert, Wolfgang, Phillips, Charlotte L., Visse, Robert, Nagase, Hideaki, Leikin, Sergey
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903388/ https://www.ncbi.nlm.nih.gov/pubmed/20463013 http://dx.doi.org/10.1074/jbc.M110.102079

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