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CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P(1)) Function through Interaction with Membrane Helix 4

Lymphocyte egress from lymph nodes requires the G-protein-coupled sphingosine 1-phosphate receptor-1 (S1P(1)). The activation antigen CD69 associates with and inhibits the function of S1P(1), inhibiting egress. Here we undertook biochemical characterization of the requirements for S1P(1)-CD69 comple...

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Detalles Bibliográficos
Autores principales:	Bankovich, Alexander J., Shiow, Lawrence R., Cyster, Jason G.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903414/ https://www.ncbi.nlm.nih.gov/pubmed/20463015 http://dx.doi.org/10.1074/jbc.M110.123299

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