Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust

Exposure to urban particulate matter has been associated with an increased risk of cardiovascular disease and thrombosis. We studied the effects of transient exposure to diesel particles on fibrin clot structure of 16 healthy individuals (age 21- 44). The subjects were randomly exposed to diesel exh...

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Autores principales: Metassan, Sofian, Routledge, Michael N, Lucking, Andrew J, de Willige, Shirley Uitte, Philippou, Helen, Mills, Nicholas L, Newby, David E, Ariëns, Robert AS
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903495/
https://www.ncbi.nlm.nih.gov/pubmed/20565709
http://dx.doi.org/10.1186/1743-8977-7-17
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author Metassan, Sofian
Routledge, Michael N
Lucking, Andrew J
de Willige, Shirley Uitte
Philippou, Helen
Mills, Nicholas L
Newby, David E
Ariëns, Robert AS
author_facet Metassan, Sofian
Routledge, Michael N
Lucking, Andrew J
de Willige, Shirley Uitte
Philippou, Helen
Mills, Nicholas L
Newby, David E
Ariëns, Robert AS
author_sort Metassan, Sofian
collection PubMed
description Exposure to urban particulate matter has been associated with an increased risk of cardiovascular disease and thrombosis. We studied the effects of transient exposure to diesel particles on fibrin clot structure of 16 healthy individuals (age 21- 44). The subjects were randomly exposed to diesel exhaust and filtered air on two separate occasions. Blood samples were collected before exposure, and 2 and 6 hours after exposure. There were no significant changes on clot permeability, maximum turbidity, lag time, fibre diameter, fibre density and fibrinogen level between samples taken after diesel exhaust exposure and samples taken after filtered air exposure. These data show that there are no prothrombotic changes in fibrin clot structure in young, healthy individuals exposed to diesel exhaust.
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spelling pubmed-29034952010-07-14 Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust Metassan, Sofian Routledge, Michael N Lucking, Andrew J de Willige, Shirley Uitte Philippou, Helen Mills, Nicholas L Newby, David E Ariëns, Robert AS Part Fibre Toxicol Short Report Exposure to urban particulate matter has been associated with an increased risk of cardiovascular disease and thrombosis. We studied the effects of transient exposure to diesel particles on fibrin clot structure of 16 healthy individuals (age 21- 44). The subjects were randomly exposed to diesel exhaust and filtered air on two separate occasions. Blood samples were collected before exposure, and 2 and 6 hours after exposure. There were no significant changes on clot permeability, maximum turbidity, lag time, fibre diameter, fibre density and fibrinogen level between samples taken after diesel exhaust exposure and samples taken after filtered air exposure. These data show that there are no prothrombotic changes in fibrin clot structure in young, healthy individuals exposed to diesel exhaust. BioMed Central 2010-06-16 /pmc/articles/PMC2903495/ /pubmed/20565709 http://dx.doi.org/10.1186/1743-8977-7-17 Text en Copyright ©2010 Metassan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Metassan, Sofian
Routledge, Michael N
Lucking, Andrew J
de Willige, Shirley Uitte
Philippou, Helen
Mills, Nicholas L
Newby, David E
Ariëns, Robert AS
Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
title Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
title_full Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
title_fullStr Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
title_full_unstemmed Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
title_short Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
title_sort fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903495/
https://www.ncbi.nlm.nih.gov/pubmed/20565709
http://dx.doi.org/10.1186/1743-8977-7-17
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