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Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

BACKGROUND: Drug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1 overexpression is most commonly detected in drug-resistant cancers and accompanied with other gene alterations including enhanced glucosylceramide synthase (GCS). MDR1 enc...

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Detalles Bibliográficos
Autores principales:	Liu, Yong-Yu, Gupta, Vineet, Patwardhan, Gauri A, Bhinge, Kaustubh, Zhao, Yunfeng, Bao, Jianxiong, Mehendale, Harihara, Cabot, Myles C, Li, Yu-Teh, Jazwinski, S Michal
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903501/ https://www.ncbi.nlm.nih.gov/pubmed/20540746 http://dx.doi.org/10.1186/1476-4598-9-145

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