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Lens Fiber Cell Differentiation and Denucleation Are Disrupted through Expression of the N-Terminal Nuclear Receptor Box of Ncoa6 and Result in p53-dependent and p53-independent Apoptosis

Nuclear receptor coactivator 6 (NCOA6) is a multifunctional protein implicated in embryonic development, cell survival, and homeostasis. An 81-amino acid fragment, dnNCOA6, containing the N-terminal nuclear receptor box (LXXLL motif) of NCOA6, acts as a dominant-negative (dn) inhibitor of NCOA6. Her...

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Detalles Bibliográficos
Autores principales:	Wang, Wei-Lin, Li, Qingtian, Xu, Jianming, Cvekl, Aleš
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903674/ https://www.ncbi.nlm.nih.gov/pubmed/20484573 http://dx.doi.org/10.1091/mbc.E09-12-1031

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