The Scaffold Protein TANK/I-TRAF Inhibits NF-κB Activation by Recruiting Polo-like Kinase 1

TANK/I-TRAF is a TRAF-binding protein that negatively regulates NF-κB activation. The underlying mechanism of this activity remains unclear. Here we show that TANK directly interacts with PLK1, a conserved cell cycle–regulated kinase. PLK1 inhibits NF-κB transcriptional activation induced by TNF-α,...

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Detalles Bibliográficos
Autores principales: Zhang, Wanqiao, Wang, Jian, Zhang, Ying, Yuan, Yanzhi, Guan, Wei, Jin, Chaozhi, Chen, Hui, Wang, Xiaohui, Yang, Xiaoming, He, Fuchu
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903677/
https://www.ncbi.nlm.nih.gov/pubmed/20484576
http://dx.doi.org/10.1091/mbc.E09-08-0715

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