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Sclerostin: Current Knowledge and Future Perspectives
In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by o...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903685/ https://www.ncbi.nlm.nih.gov/pubmed/20473488 http://dx.doi.org/10.1007/s00223-010-9372-1 |
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author | Moester, M. J. C. Papapoulos, S. E. Löwik, C. W. G. M. van Bezooijen, R. L. |
author_facet | Moester, M. J. C. Papapoulos, S. E. Löwik, C. W. G. M. van Bezooijen, R. L. |
author_sort | Moester, M. J. C. |
collection | PubMed |
description | In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by osteocytes that inhibits bone formation by osteoblasts. The restricted expression pattern of sclerostin in the skeleton and the exclusive bone phenotype of good quality of patients with sclerosteosis and van Buchem disease provide the basis for the design of therapeutics that stimulate bone formation. We review here current knowledge of the regulation of the expression and formation of sclerostin, its mechanism of action, and its potential as a bone-building treatment for patients with osteoporosis. |
format | Text |
id | pubmed-2903685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-29036852010-08-06 Sclerostin: Current Knowledge and Future Perspectives Moester, M. J. C. Papapoulos, S. E. Löwik, C. W. G. M. van Bezooijen, R. L. Calcif Tissue Int Review In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by osteocytes that inhibits bone formation by osteoblasts. The restricted expression pattern of sclerostin in the skeleton and the exclusive bone phenotype of good quality of patients with sclerosteosis and van Buchem disease provide the basis for the design of therapeutics that stimulate bone formation. We review here current knowledge of the regulation of the expression and formation of sclerostin, its mechanism of action, and its potential as a bone-building treatment for patients with osteoporosis. Springer-Verlag 2010-05-15 2010 /pmc/articles/PMC2903685/ /pubmed/20473488 http://dx.doi.org/10.1007/s00223-010-9372-1 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Moester, M. J. C. Papapoulos, S. E. Löwik, C. W. G. M. van Bezooijen, R. L. Sclerostin: Current Knowledge and Future Perspectives |
title | Sclerostin: Current Knowledge and Future Perspectives |
title_full | Sclerostin: Current Knowledge and Future Perspectives |
title_fullStr | Sclerostin: Current Knowledge and Future Perspectives |
title_full_unstemmed | Sclerostin: Current Knowledge and Future Perspectives |
title_short | Sclerostin: Current Knowledge and Future Perspectives |
title_sort | sclerostin: current knowledge and future perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903685/ https://www.ncbi.nlm.nih.gov/pubmed/20473488 http://dx.doi.org/10.1007/s00223-010-9372-1 |
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