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Sclerostin: Current Knowledge and Future Perspectives

In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by o...

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Autores principales: Moester, M. J. C., Papapoulos, S. E., Löwik, C. W. G. M., van Bezooijen, R. L.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903685/
https://www.ncbi.nlm.nih.gov/pubmed/20473488
http://dx.doi.org/10.1007/s00223-010-9372-1
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author Moester, M. J. C.
Papapoulos, S. E.
Löwik, C. W. G. M.
van Bezooijen, R. L.
author_facet Moester, M. J. C.
Papapoulos, S. E.
Löwik, C. W. G. M.
van Bezooijen, R. L.
author_sort Moester, M. J. C.
collection PubMed
description In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by osteocytes that inhibits bone formation by osteoblasts. The restricted expression pattern of sclerostin in the skeleton and the exclusive bone phenotype of good quality of patients with sclerosteosis and van Buchem disease provide the basis for the design of therapeutics that stimulate bone formation. We review here current knowledge of the regulation of the expression and formation of sclerostin, its mechanism of action, and its potential as a bone-building treatment for patients with osteoporosis.
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spelling pubmed-29036852010-08-06 Sclerostin: Current Knowledge and Future Perspectives Moester, M. J. C. Papapoulos, S. E. Löwik, C. W. G. M. van Bezooijen, R. L. Calcif Tissue Int Review In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by osteocytes that inhibits bone formation by osteoblasts. The restricted expression pattern of sclerostin in the skeleton and the exclusive bone phenotype of good quality of patients with sclerosteosis and van Buchem disease provide the basis for the design of therapeutics that stimulate bone formation. We review here current knowledge of the regulation of the expression and formation of sclerostin, its mechanism of action, and its potential as a bone-building treatment for patients with osteoporosis. Springer-Verlag 2010-05-15 2010 /pmc/articles/PMC2903685/ /pubmed/20473488 http://dx.doi.org/10.1007/s00223-010-9372-1 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Review
Moester, M. J. C.
Papapoulos, S. E.
Löwik, C. W. G. M.
van Bezooijen, R. L.
Sclerostin: Current Knowledge and Future Perspectives
title Sclerostin: Current Knowledge and Future Perspectives
title_full Sclerostin: Current Knowledge and Future Perspectives
title_fullStr Sclerostin: Current Knowledge and Future Perspectives
title_full_unstemmed Sclerostin: Current Knowledge and Future Perspectives
title_short Sclerostin: Current Knowledge and Future Perspectives
title_sort sclerostin: current knowledge and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903685/
https://www.ncbi.nlm.nih.gov/pubmed/20473488
http://dx.doi.org/10.1007/s00223-010-9372-1
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