Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus

Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimate...

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Autores principales: van den Oever, Inge A. M., Raterman, Hennie G., Nurmohamed, Mike T., Simsek, Suat
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903979/
https://www.ncbi.nlm.nih.gov/pubmed/20634940
http://dx.doi.org/10.1155/2010/792393
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author van den Oever, Inge A. M.
Raterman, Hennie G.
Nurmohamed, Mike T.
Simsek, Suat
author_facet van den Oever, Inge A. M.
Raterman, Hennie G.
Nurmohamed, Mike T.
Simsek, Suat
author_sort van den Oever, Inge A. M.
collection PubMed
description Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.
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spelling pubmed-29039792010-07-15 Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus van den Oever, Inge A. M. Raterman, Hennie G. Nurmohamed, Mike T. Simsek, Suat Mediators Inflamm Review Article Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus. Hindawi Publishing Corporation 2010 2010-06-15 /pmc/articles/PMC2903979/ /pubmed/20634940 http://dx.doi.org/10.1155/2010/792393 Text en Copyright © 2010 Inge A. M. van den Oever et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
van den Oever, Inge A. M.
Raterman, Hennie G.
Nurmohamed, Mike T.
Simsek, Suat
Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
title Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
title_full Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
title_fullStr Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
title_full_unstemmed Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
title_short Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus
title_sort endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903979/
https://www.ncbi.nlm.nih.gov/pubmed/20634940
http://dx.doi.org/10.1155/2010/792393
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AT ratermanhennieg endothelialdysfunctioninflammationandapoptosisindiabetesmellitus
AT nurmohamedmiket endothelialdysfunctioninflammationandapoptosisindiabetesmellitus
AT simseksuat endothelialdysfunctioninflammationandapoptosisindiabetesmellitus

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