Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry

Readouts that define the physiological distributions of drugs in tissues are an unmet challenge and at best imprecise, but are needed in order to understand both the pharmacokinetic and pharmacodynamic properties associated with efficacy. Here we demonstrate that it is feasible to follow the in vivo...

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Detalles Bibliográficos
Autores principales: Nilsson, Anna, Fehniger, Thomas E., Gustavsson, Lena, Andersson, Malin, Kenne, Kerstin, Marko-Varga, György, Andrén, Per E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904372/
https://www.ncbi.nlm.nih.gov/pubmed/20644728
http://dx.doi.org/10.1371/journal.pone.0011411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904372/
https://www.ncbi.nlm.nih.gov/pubmed/20644728
http://dx.doi.org/10.1371/journal.pone.0011411

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