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Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

SpyCEP is a Streptococcus pyogenes protease that cleaves CXCL8/IL-8 and its activity is associated with human invasive disease severity. We investigated the role of SpyCEP in S. pyogenes necrotizing fasciitis and respiratory tract infection in mice using isogenic strains differing only in SpyCEP exp...

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Detalles Bibliográficos
Autores principales:	Kurupati, Prathiba, Turner, Claire E, Tziona, Ioanna, Lawrenson, Richard A, Alam, Faraz M, Nohadani, Mahrokh, Stamp, Gordon W, Zinkernagel, Annelies S, Nizet, Victor, Edwards, Robert J, Sriskandan, Shiranee
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2010
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904501/ https://www.ncbi.nlm.nih.gov/pubmed/20158613 http://dx.doi.org/10.1111/j.1365-2958.2010.07065.x

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