Cargando…
Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord
A multi-electrode array (MEA) was implanted in the dorsolateral funiculus of the cervical spinal cord to record descending information during behavior in freely moving rats. Neural signals were characterized in terms of frequency and information content. Frequency analysis revealed components both a...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904587/ https://www.ncbi.nlm.nih.gov/pubmed/20589238 http://dx.doi.org/10.3389/fnins.2010.00021 |
_version_ | 1782183888720756736 |
---|---|
author | Prasad, Abhishek Sahin, Mesut |
author_facet | Prasad, Abhishek Sahin, Mesut |
author_sort | Prasad, Abhishek |
collection | PubMed |
description | A multi-electrode array (MEA) was implanted in the dorsolateral funiculus of the cervical spinal cord to record descending information during behavior in freely moving rats. Neural signals were characterized in terms of frequency and information content. Frequency analysis revealed components both at the range of local field potentials and multi-unit activity. Coherence between channels decreased steadily with inter-contact distance and frequency suggesting greater spatial selectivity for multi-unit activity compared to local field potentials. Principal component analysis (PCA) extracted multiple channels of neural activity with patterns that correlated to the behavior, indicating multiple dimensionality of the signals. Two different behaviors involving the forelimbs, face cleaning and food reaching, generated neural signals through distinctly different combination of neural channels, which suggested that these two behaviors could readily be differentiated from recordings. This preliminary data demonstrated that descending spinal cord signals recorded with MEAs can be used to extract multiple channels of command control information and potentially be utilized as a means of communication in high level spinal cord injury subjects. |
format | Text |
id | pubmed-2904587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29045872010-08-20 Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord Prasad, Abhishek Sahin, Mesut Front Neurosci Neuroscience A multi-electrode array (MEA) was implanted in the dorsolateral funiculus of the cervical spinal cord to record descending information during behavior in freely moving rats. Neural signals were characterized in terms of frequency and information content. Frequency analysis revealed components both at the range of local field potentials and multi-unit activity. Coherence between channels decreased steadily with inter-contact distance and frequency suggesting greater spatial selectivity for multi-unit activity compared to local field potentials. Principal component analysis (PCA) extracted multiple channels of neural activity with patterns that correlated to the behavior, indicating multiple dimensionality of the signals. Two different behaviors involving the forelimbs, face cleaning and food reaching, generated neural signals through distinctly different combination of neural channels, which suggested that these two behaviors could readily be differentiated from recordings. This preliminary data demonstrated that descending spinal cord signals recorded with MEAs can be used to extract multiple channels of command control information and potentially be utilized as a means of communication in high level spinal cord injury subjects. Frontiers Research Foundation 2010-06-02 /pmc/articles/PMC2904587/ /pubmed/20589238 http://dx.doi.org/10.3389/fnins.2010.00021 Text en Copyright © 2010 Prasad and Sahin. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. |
spellingShingle | Neuroscience Prasad, Abhishek Sahin, Mesut Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord |
title | Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord |
title_full | Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord |
title_fullStr | Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord |
title_full_unstemmed | Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord |
title_short | Characterization of Neural Activity Recorded from the Descending Tracts of the Rat Spinal Cord |
title_sort | characterization of neural activity recorded from the descending tracts of the rat spinal cord |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904587/ https://www.ncbi.nlm.nih.gov/pubmed/20589238 http://dx.doi.org/10.3389/fnins.2010.00021 |
work_keys_str_mv | AT prasadabhishek characterizationofneuralactivityrecordedfromthedescendingtractsoftheratspinalcord AT sahinmesut characterizationofneuralactivityrecordedfromthedescendingtractsoftheratspinalcord |