Cargando…

The Non-Lemniscal Auditory Cortex in Ferrets: Convergence of Corticotectal Inputs in the Superior Colliculus

Descending cortical inputs to the superior colliculus (SC) contribute to the unisensory response properties of the neurons found there and are critical for multisensory integration. However, little is known about the relative contribution of different auditory cortical areas to this projection or th...

Descripción completa

Detalles Bibliográficos
Autores principales: Bajo, Victoria M., Nodal, Fernando R., Bizley, Jennifer K., King, Andrew J.
Formato: Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904598/
https://www.ncbi.nlm.nih.gov/pubmed/20640247
http://dx.doi.org/10.3389/fnana.2010.00018
_version_ 1782183889692786688
author Bajo, Victoria M.
Nodal, Fernando R.
Bizley, Jennifer K.
King, Andrew J.
author_facet Bajo, Victoria M.
Nodal, Fernando R.
Bizley, Jennifer K.
King, Andrew J.
author_sort Bajo, Victoria M.
collection PubMed
description Descending cortical inputs to the superior colliculus (SC) contribute to the unisensory response properties of the neurons found there and are critical for multisensory integration. However, little is known about the relative contribution of different auditory cortical areas to this projection or the distribution of their terminals in the SC. We characterized this projection in the ferret by injecting tracers in the SC and auditory cortex. Large pyramidal neurons were labeled in layer V of different parts of the ectosylvian gyrus after tracer injections in the SC. Those cells were most numerous in the anterior ectosylvian gyrus (AEG), and particularly in the anterior ventral field, which receives both auditory and visual inputs. Labeling was also found in the posterior ectosylvian gyrus (PEG), predominantly in the tonotopically organized posterior suprasylvian field. Profuse anterograde labeling was present in the SC following tracer injections at the site of acoustically responsive neurons in the AEG or PEG, with terminal fields being both more prominent and clustered for inputs originating from the AEG. Terminals from both cortical areas were located throughout the intermediate and deep layers, but were most concentrated in the posterior half of the SC, where peripheral stimulus locations are represented. No inputs were identified from primary auditory cortical areas, although some labeling was found in the surrounding sulci. Our findings suggest that higher level auditory cortical areas, including those involved in multisensory processing, may modulate SC function via their projections into its deeper layers.
format Text
id pubmed-2904598
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Frontiers Research Foundation
record_format MEDLINE/PubMed
spelling pubmed-29045982010-07-16 The Non-Lemniscal Auditory Cortex in Ferrets: Convergence of Corticotectal Inputs in the Superior Colliculus Bajo, Victoria M. Nodal, Fernando R. Bizley, Jennifer K. King, Andrew J. Front Neuroanat Neuroscience Descending cortical inputs to the superior colliculus (SC) contribute to the unisensory response properties of the neurons found there and are critical for multisensory integration. However, little is known about the relative contribution of different auditory cortical areas to this projection or the distribution of their terminals in the SC. We characterized this projection in the ferret by injecting tracers in the SC and auditory cortex. Large pyramidal neurons were labeled in layer V of different parts of the ectosylvian gyrus after tracer injections in the SC. Those cells were most numerous in the anterior ectosylvian gyrus (AEG), and particularly in the anterior ventral field, which receives both auditory and visual inputs. Labeling was also found in the posterior ectosylvian gyrus (PEG), predominantly in the tonotopically organized posterior suprasylvian field. Profuse anterograde labeling was present in the SC following tracer injections at the site of acoustically responsive neurons in the AEG or PEG, with terminal fields being both more prominent and clustered for inputs originating from the AEG. Terminals from both cortical areas were located throughout the intermediate and deep layers, but were most concentrated in the posterior half of the SC, where peripheral stimulus locations are represented. No inputs were identified from primary auditory cortical areas, although some labeling was found in the surrounding sulci. Our findings suggest that higher level auditory cortical areas, including those involved in multisensory processing, may modulate SC function via their projections into its deeper layers. Frontiers Research Foundation 2010-05-21 /pmc/articles/PMC2904598/ /pubmed/20640247 http://dx.doi.org/10.3389/fnana.2010.00018 Text en Copyright © 2010 Bajo, Nodal, Bizley and King. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
spellingShingle Neuroscience
Bajo, Victoria M.
Nodal, Fernando R.
Bizley, Jennifer K.
King, Andrew J.
The Non-Lemniscal Auditory Cortex in Ferrets: Convergence of Corticotectal Inputs in the Superior Colliculus
title The Non-Lemniscal Auditory Cortex in Ferrets: Convergence of Corticotectal Inputs in the Superior Colliculus
title_full The Non-Lemniscal Auditory Cortex in Ferrets: Convergence of Corticotectal Inputs in the Superior Colliculus
title_fullStr The Non-Lemniscal Auditory Cortex in Ferrets: Convergence of Corticotectal Inputs in the Superior Colliculus
title_full_unstemmed The Non-Lemniscal Auditory Cortex in Ferrets: Convergence of Corticotectal Inputs in the Superior Colliculus
title_short The Non-Lemniscal Auditory Cortex in Ferrets: Convergence of Corticotectal Inputs in the Superior Colliculus
title_sort non-lemniscal auditory cortex in ferrets: convergence of corticotectal inputs in the superior colliculus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904598/
https://www.ncbi.nlm.nih.gov/pubmed/20640247
http://dx.doi.org/10.3389/fnana.2010.00018
work_keys_str_mv AT bajovictoriam thenonlemniscalauditorycortexinferretsconvergenceofcorticotectalinputsinthesuperiorcolliculus
AT nodalfernandor thenonlemniscalauditorycortexinferretsconvergenceofcorticotectalinputsinthesuperiorcolliculus
AT bizleyjenniferk thenonlemniscalauditorycortexinferretsconvergenceofcorticotectalinputsinthesuperiorcolliculus
AT kingandrewj thenonlemniscalauditorycortexinferretsconvergenceofcorticotectalinputsinthesuperiorcolliculus
AT bajovictoriam nonlemniscalauditorycortexinferretsconvergenceofcorticotectalinputsinthesuperiorcolliculus
AT nodalfernandor nonlemniscalauditorycortexinferretsconvergenceofcorticotectalinputsinthesuperiorcolliculus
AT bizleyjenniferk nonlemniscalauditorycortexinferretsconvergenceofcorticotectalinputsinthesuperiorcolliculus
AT kingandrewj nonlemniscalauditorycortexinferretsconvergenceofcorticotectalinputsinthesuperiorcolliculus