Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice

BACKGROUND: We previously demonstrated that cyclooxygenase (COX)-1 deficiency results in greater morbidity and inflammation, whereas COX-2 deficiency leads to reduced morbidity, inflammation and mortality in influenza infected mice. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the effects of COX-...

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Detalles Bibliográficos
Autores principales: Carey, Michelle A., Bradbury, J. Alyce, Rebolloso, Yvette D., Graves, Joan P., Zeldin, Darryl C., Germolec, Dori R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904706/
https://www.ncbi.nlm.nih.gov/pubmed/20657653
http://dx.doi.org/10.1371/journal.pone.0011610

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