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The function and structure of the cerebrospinal fluid outflow system
This review traces the development of our understanding of the anatomy and physiological properties of the two systems responsible for the drainage of cerebrospinal fluid (CSF) into the systemic circulation. The roles of the cranial and spinal arachnoid villi (AV) and the lymphatic outflow systems a...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904716/ https://www.ncbi.nlm.nih.gov/pubmed/20565964 http://dx.doi.org/10.1186/1743-8454-7-9 |
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author | Pollay, Michael |
author_facet | Pollay, Michael |
author_sort | Pollay, Michael |
collection | PubMed |
description | This review traces the development of our understanding of the anatomy and physiological properties of the two systems responsible for the drainage of cerebrospinal fluid (CSF) into the systemic circulation. The roles of the cranial and spinal arachnoid villi (AV) and the lymphatic outflow systems are evaluated as to the dominance of one over the other in various species and degree of animal maturation. The functional capabilities of the total CSF drainage system are presented, with evidence that the duality of the system is supported by the changes in fluid outflow dynamics in human and sub-human primates in hydrocephalus. The review also reconciles the relative importance and alterations of each of the outflow systems in a variety of clinical pathological conditions. |
format | Text |
id | pubmed-2904716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29047162010-07-16 The function and structure of the cerebrospinal fluid outflow system Pollay, Michael Cerebrospinal Fluid Res Review This review traces the development of our understanding of the anatomy and physiological properties of the two systems responsible for the drainage of cerebrospinal fluid (CSF) into the systemic circulation. The roles of the cranial and spinal arachnoid villi (AV) and the lymphatic outflow systems are evaluated as to the dominance of one over the other in various species and degree of animal maturation. The functional capabilities of the total CSF drainage system are presented, with evidence that the duality of the system is supported by the changes in fluid outflow dynamics in human and sub-human primates in hydrocephalus. The review also reconciles the relative importance and alterations of each of the outflow systems in a variety of clinical pathological conditions. BioMed Central 2010-06-21 /pmc/articles/PMC2904716/ /pubmed/20565964 http://dx.doi.org/10.1186/1743-8454-7-9 Text en Copyright ©2010 Pollay; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Pollay, Michael The function and structure of the cerebrospinal fluid outflow system |
title | The function and structure of the cerebrospinal fluid outflow system |
title_full | The function and structure of the cerebrospinal fluid outflow system |
title_fullStr | The function and structure of the cerebrospinal fluid outflow system |
title_full_unstemmed | The function and structure of the cerebrospinal fluid outflow system |
title_short | The function and structure of the cerebrospinal fluid outflow system |
title_sort | function and structure of the cerebrospinal fluid outflow system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904716/ https://www.ncbi.nlm.nih.gov/pubmed/20565964 http://dx.doi.org/10.1186/1743-8454-7-9 |
work_keys_str_mv | AT pollaymichael thefunctionandstructureofthecerebrospinalfluidoutflowsystem AT pollaymichael functionandstructureofthecerebrospinalfluidoutflowsystem |