Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma

Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma...

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Autores principales: Ye, Feng, Yu, Yan, Hu, Yuting, Lu, Weiguo, Xie, Xing
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904720/
https://www.ncbi.nlm.nih.gov/pubmed/20565840
http://dx.doi.org/10.1186/1756-9966-29-78
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author Ye, Feng
Yu, Yan
Hu, Yuting
Lu, Weiguo
Xie, Xing
author_facet Ye, Feng
Yu, Yan
Hu, Yuting
Lu, Weiguo
Xie, Xing
author_sort Ye, Feng
collection PubMed
description Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with CIN, and 62 healthy individuals. A substantial reduction of circulating dendritic cells and accordingly immunodepression may be associated with increased IL-6 and TGF-β in serum. These findings could give expression to the immunosuppression of circulating dendritic cells in patients with CC and CIN, thus, may indicate novel aspects of cervical carcinoma immune evasion.
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spelling pubmed-29047202010-07-16 Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma Ye, Feng Yu, Yan Hu, Yuting Lu, Weiguo Xie, Xing J Exp Clin Cancer Res Research Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with CIN, and 62 healthy individuals. A substantial reduction of circulating dendritic cells and accordingly immunodepression may be associated with increased IL-6 and TGF-β in serum. These findings could give expression to the immunosuppression of circulating dendritic cells in patients with CC and CIN, thus, may indicate novel aspects of cervical carcinoma immune evasion. BioMed Central 2010-06-18 /pmc/articles/PMC2904720/ /pubmed/20565840 http://dx.doi.org/10.1186/1756-9966-29-78 Text en Copyright ©2010 Feng et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ye, Feng
Yu, Yan
Hu, Yuting
Lu, Weiguo
Xie, Xing
Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
title Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
title_full Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
title_fullStr Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
title_full_unstemmed Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
title_short Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
title_sort alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904720/
https://www.ncbi.nlm.nih.gov/pubmed/20565840
http://dx.doi.org/10.1186/1756-9966-29-78
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