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Lipid profile in consecutive pregnancies
AIM: To describe the lipid profile of women prior to, during and after pregnancy and to assess the effect of consecutive pregnancies on the plasma lipid profile. METHODS: Blood lipid levels of 1752 women aged 20-45 years who delivered between 1999 and 2005 were measured. The lipid profile included t...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904773/ https://www.ncbi.nlm.nih.gov/pubmed/20525387 http://dx.doi.org/10.1186/1476-511X-9-58 |
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author | Mankuta, David Elami-Suzin, Matan Elhayani, Asher Vinker, Shlomo |
author_facet | Mankuta, David Elami-Suzin, Matan Elhayani, Asher Vinker, Shlomo |
author_sort | Mankuta, David |
collection | PubMed |
description | AIM: To describe the lipid profile of women prior to, during and after pregnancy and to assess the effect of consecutive pregnancies on the plasma lipid profile. METHODS: Blood lipid levels of 1752 women aged 20-45 years who delivered between 1999 and 2005 were measured. The lipid profile included total cholesterol, LDL-C (Low density lipoprotein), HDL-C (High density lipoprotein-C), VLDL-C (Very low density lipoprotein) and triglycerides (TG). The measurements were classified into the following categories: non-pregnant state (12 months prior to conception), during the three trimesters of pregnancy and from 6 weeks to 12 months postpartum. This profile was tested in up to three subsequent pregnancies. RESULTS: Total cholesterol levels overall rose during pregnancy. In the first trimester there is an average decrease of 11.4 mg/dL in total cholesterol level (p < 0.0001) followed by an average increase of 50.5 mg/dL and 28 mg/dL in the second and third trimesters respectively (p < 0.0001). In the year after pregnancy, the levels return to pre- pregnancy levels. LDL and triglyceride levels show a similar pattern. In contrast, HDL-C levels do not change significantly in the first trimester. The second trimester is characterized by an average elevation of 14 mg/dL (p < 0.0001) and a decrease of 5 mg/dL in the third trimester (p = 0.03). The average HDL-C levels of every period tested were lower in the 2nd and 3rd subsequent pregnancies. CONCLUSIONS: There is a general increase in total cholesterol, LDL and VLDL during pregnancy. We demonstrate a cumulative effect of consecutive pregnancies on lowering HDL cholesterol levels. This effect may have negative implications on future cardiovascular health. |
format | Text |
id | pubmed-2904773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-29047732010-07-16 Lipid profile in consecutive pregnancies Mankuta, David Elami-Suzin, Matan Elhayani, Asher Vinker, Shlomo Lipids Health Dis Research AIM: To describe the lipid profile of women prior to, during and after pregnancy and to assess the effect of consecutive pregnancies on the plasma lipid profile. METHODS: Blood lipid levels of 1752 women aged 20-45 years who delivered between 1999 and 2005 were measured. The lipid profile included total cholesterol, LDL-C (Low density lipoprotein), HDL-C (High density lipoprotein-C), VLDL-C (Very low density lipoprotein) and triglycerides (TG). The measurements were classified into the following categories: non-pregnant state (12 months prior to conception), during the three trimesters of pregnancy and from 6 weeks to 12 months postpartum. This profile was tested in up to three subsequent pregnancies. RESULTS: Total cholesterol levels overall rose during pregnancy. In the first trimester there is an average decrease of 11.4 mg/dL in total cholesterol level (p < 0.0001) followed by an average increase of 50.5 mg/dL and 28 mg/dL in the second and third trimesters respectively (p < 0.0001). In the year after pregnancy, the levels return to pre- pregnancy levels. LDL and triglyceride levels show a similar pattern. In contrast, HDL-C levels do not change significantly in the first trimester. The second trimester is characterized by an average elevation of 14 mg/dL (p < 0.0001) and a decrease of 5 mg/dL in the third trimester (p = 0.03). The average HDL-C levels of every period tested were lower in the 2nd and 3rd subsequent pregnancies. CONCLUSIONS: There is a general increase in total cholesterol, LDL and VLDL during pregnancy. We demonstrate a cumulative effect of consecutive pregnancies on lowering HDL cholesterol levels. This effect may have negative implications on future cardiovascular health. BioMed Central 2010-06-05 /pmc/articles/PMC2904773/ /pubmed/20525387 http://dx.doi.org/10.1186/1476-511X-9-58 Text en Copyright ©2010 Mankuta et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Mankuta, David Elami-Suzin, Matan Elhayani, Asher Vinker, Shlomo Lipid profile in consecutive pregnancies |
title | Lipid profile in consecutive pregnancies |
title_full | Lipid profile in consecutive pregnancies |
title_fullStr | Lipid profile in consecutive pregnancies |
title_full_unstemmed | Lipid profile in consecutive pregnancies |
title_short | Lipid profile in consecutive pregnancies |
title_sort | lipid profile in consecutive pregnancies |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904773/ https://www.ncbi.nlm.nih.gov/pubmed/20525387 http://dx.doi.org/10.1186/1476-511X-9-58 |
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