Pancytopenia due to proguanil toxicity in a returning traveller with fever

A patient known to have renal insufficiency was admitted to the hospital with fever and pancytopenia after returning from a trip to Mali. Pancytopenia was not caused by a tropical infection but was a side effect of atovaquone/proguanil used as malaria chemoprophylaxis. High and prolonged detectable...

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Detalles Bibliográficos
Autores principales: Jolink, Hetty, den Hartigh, Jan, Visser, Leo G., van Nieuwkoop, Cees
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904905/
https://www.ncbi.nlm.nih.gov/pubmed/20407763
http://dx.doi.org/10.1007/s00228-010-0824-3
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author Jolink, Hetty
den Hartigh, Jan
Visser, Leo G.
van Nieuwkoop, Cees
author_facet Jolink, Hetty
den Hartigh, Jan
Visser, Leo G.
van Nieuwkoop, Cees
author_sort Jolink, Hetty
collection PubMed
description A patient known to have renal insufficiency was admitted to the hospital with fever and pancytopenia after returning from a trip to Mali. Pancytopenia was not caused by a tropical infection but was a side effect of atovaquone/proguanil used as malaria chemoprophylaxis. High and prolonged detectable proguanil serum levels can result in bone marrow suppression in patients with renal insufficiency. This should be taken into account in a returning traveller with fever and pancytopenia.
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spelling pubmed-29049052010-08-06 Pancytopenia due to proguanil toxicity in a returning traveller with fever Jolink, Hetty den Hartigh, Jan Visser, Leo G. van Nieuwkoop, Cees Eur J Clin Pharmacol Pharmacokinetics and Disposition A patient known to have renal insufficiency was admitted to the hospital with fever and pancytopenia after returning from a trip to Mali. Pancytopenia was not caused by a tropical infection but was a side effect of atovaquone/proguanil used as malaria chemoprophylaxis. High and prolonged detectable proguanil serum levels can result in bone marrow suppression in patients with renal insufficiency. This should be taken into account in a returning traveller with fever and pancytopenia. Springer-Verlag 2010-04-21 2010 /pmc/articles/PMC2904905/ /pubmed/20407763 http://dx.doi.org/10.1007/s00228-010-0824-3 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Pharmacokinetics and Disposition
Jolink, Hetty
den Hartigh, Jan
Visser, Leo G.
van Nieuwkoop, Cees
Pancytopenia due to proguanil toxicity in a returning traveller with fever
title Pancytopenia due to proguanil toxicity in a returning traveller with fever
title_full Pancytopenia due to proguanil toxicity in a returning traveller with fever
title_fullStr Pancytopenia due to proguanil toxicity in a returning traveller with fever
title_full_unstemmed Pancytopenia due to proguanil toxicity in a returning traveller with fever
title_short Pancytopenia due to proguanil toxicity in a returning traveller with fever
title_sort pancytopenia due to proguanil toxicity in a returning traveller with fever
topic Pharmacokinetics and Disposition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904905/
https://www.ncbi.nlm.nih.gov/pubmed/20407763
http://dx.doi.org/10.1007/s00228-010-0824-3
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AT denhartighjan pancytopeniaduetoproguaniltoxicityinareturningtravellerwithfever
AT visserleog pancytopeniaduetoproguaniltoxicityinareturningtravellerwithfever
AT vannieuwkoopcees pancytopeniaduetoproguaniltoxicityinareturningtravellerwithfever

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