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Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells

Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cry...

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Detalles Bibliográficos
Autores principales: Gimble, Jeffrey M, Guilak, Farshid, Bunnell, Bruce A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905095/
https://www.ncbi.nlm.nih.gov/pubmed/20587076
http://dx.doi.org/10.1186/scrt19
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author Gimble, Jeffrey M
Guilak, Farshid
Bunnell, Bruce A
author_facet Gimble, Jeffrey M
Guilak, Farshid
Bunnell, Bruce A
author_sort Gimble, Jeffrey M
collection PubMed
description Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models. This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. The present article reviews the case reports and phase I-III clinical evidence using autologous adipose-derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. Future directions and challenges facing the field are discussed and evaluated.
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spelling pubmed-29050952011-06-29 Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells Gimble, Jeffrey M Guilak, Farshid Bunnell, Bruce A Stem Cell Res Ther Review Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models. This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. The present article reviews the case reports and phase I-III clinical evidence using autologous adipose-derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. Future directions and challenges facing the field are discussed and evaluated. BioMed Central 2010-06-29 /pmc/articles/PMC2905095/ /pubmed/20587076 http://dx.doi.org/10.1186/scrt19 Text en Copyright ©2010 BioMed Central Ltd
spellingShingle Review
Gimble, Jeffrey M
Guilak, Farshid
Bunnell, Bruce A
Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
title Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
title_full Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
title_fullStr Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
title_full_unstemmed Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
title_short Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
title_sort clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905095/
https://www.ncbi.nlm.nih.gov/pubmed/20587076
http://dx.doi.org/10.1186/scrt19
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