The HAC1 gene from Pichia pastoris: characterization and effect of its overexpression on the production of secreted, surface displayed and membrane proteins

BACKGROUND: The unfolded protein response (UPR) in eukaryotes upregulates factors that restore ER homeostasis upon protein folding stress and in yeast is activated by a non-conventional splicing of the HAC1 mRNA. The spliced HAC1 mRNA encodes an active transcription factor that binds to UPR-responsi...

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Detalles Bibliográficos
Autores principales: Guerfal, Mouna, Ryckaert, Stefan, Jacobs, Pieter P, Ameloot, Paul, Van Craenenbroeck, Kathleen, Derycke, Riet, Callewaert, Nico
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905327/
https://www.ncbi.nlm.nih.gov/pubmed/20591165
http://dx.doi.org/10.1186/1475-2859-9-49

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