Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing

Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industr...

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Autores principales: Seidle, Troy, Robinson, Sally, Holmes, Tom, Creton, Stuart, Prieto, Pilar, Scheel, Julia, Chlebus, Magda
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905404/
https://www.ncbi.nlm.nih.gov/pubmed/20484382
http://dx.doi.org/10.1093/toxsci/kfq143
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author Seidle, Troy
Robinson, Sally
Holmes, Tom
Creton, Stuart
Prieto, Pilar
Scheel, Julia
Chlebus, Magda
author_facet Seidle, Troy
Robinson, Sally
Holmes, Tom
Creton, Stuart
Prieto, Pilar
Scheel, Julia
Chlebus, Magda
author_sort Seidle, Troy
collection PubMed
description Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to identify (1) regulatory and scientific drivers for acute toxicity testing in other industrial sectors, (2) activities aimed at replacing, reducing, or refining the use of animals, and (3) recommendations for future work in this area.
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spelling pubmed-29054042010-07-19 Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing Seidle, Troy Robinson, Sally Holmes, Tom Creton, Stuart Prieto, Pilar Scheel, Julia Chlebus, Magda Toxicol Sci Forum Acute systemic toxicity studies are carried out in many sectors in which synthetic chemicals are manufactured or used and are among the most criticized of all toxicology tests on both scientific and ethical grounds. A review of the drivers for acute toxicity testing within the pharmaceutical industry led to a paradigm shift whereby in vivo acute toxicity data are no longer routinely required in advance of human clinical trials. Based on this experience, the following review was undertaken to identify (1) regulatory and scientific drivers for acute toxicity testing in other industrial sectors, (2) activities aimed at replacing, reducing, or refining the use of animals, and (3) recommendations for future work in this area. Oxford University Press 2010-08 2010-05-19 /pmc/articles/PMC2905404/ /pubmed/20484382 http://dx.doi.org/10.1093/toxsci/kfq143 Text en © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. For permissions, please email: journals.permissions@oxfordjournals.org. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Forum
Seidle, Troy
Robinson, Sally
Holmes, Tom
Creton, Stuart
Prieto, Pilar
Scheel, Julia
Chlebus, Magda
Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing
title Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing
title_full Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing
title_fullStr Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing
title_full_unstemmed Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing
title_short Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing
title_sort cross-sector review of drivers and available 3rs approaches for acute systemic toxicity testing
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905404/
https://www.ncbi.nlm.nih.gov/pubmed/20484382
http://dx.doi.org/10.1093/toxsci/kfq143
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