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Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nu...

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Detalles Bibliográficos
Autores principales: Kraemer, Doris M, Tony, Hans-Peter
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905771/
https://www.ncbi.nlm.nih.gov/pubmed/20648220
http://dx.doi.org/10.2174/1874312901004010024
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author Kraemer, Doris M
Tony, Hans-Peter
author_facet Kraemer, Doris M
Tony, Hans-Peter
author_sort Kraemer, Doris M
collection PubMed
description Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. In this paper we evaluate anti-nucleoporin p62 antibodies by western blot analysis in 25 systemic lupus erythematosus patients. Six patients showed antibodies directed against nucleoporin p62. Our data indicate that p62 antibodies could be a useful additional marker in SLE.
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spelling pubmed-29057712010-07-20 Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus Kraemer, Doris M Tony, Hans-Peter Open Rheumatol J Article Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. In this paper we evaluate anti-nucleoporin p62 antibodies by western blot analysis in 25 systemic lupus erythematosus patients. Six patients showed antibodies directed against nucleoporin p62. Our data indicate that p62 antibodies could be a useful additional marker in SLE. Bentham Open 2010-05-13 /pmc/articles/PMC2905771/ /pubmed/20648220 http://dx.doi.org/10.2174/1874312901004010024 Text en © Kraemer and Tony; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Kraemer, Doris M
Tony, Hans-Peter
Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
title Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
title_full Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
title_fullStr Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
title_full_unstemmed Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
title_short Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
title_sort nuclear pore protein p62 autoantibodies in systemic lupus erythematosus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905771/
https://www.ncbi.nlm.nih.gov/pubmed/20648220
http://dx.doi.org/10.2174/1874312901004010024
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