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Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nu...
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Formato: | Texto |
Lenguaje: | English |
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Bentham Open
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905771/ https://www.ncbi.nlm.nih.gov/pubmed/20648220 http://dx.doi.org/10.2174/1874312901004010024 |
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author | Kraemer, Doris M Tony, Hans-Peter |
author_facet | Kraemer, Doris M Tony, Hans-Peter |
author_sort | Kraemer, Doris M |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. In this paper we evaluate anti-nucleoporin p62 antibodies by western blot analysis in 25 systemic lupus erythematosus patients. Six patients showed antibodies directed against nucleoporin p62. Our data indicate that p62 antibodies could be a useful additional marker in SLE. |
format | Text |
id | pubmed-2905771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-29057712010-07-20 Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus Kraemer, Doris M Tony, Hans-Peter Open Rheumatol J Article Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. In this paper we evaluate anti-nucleoporin p62 antibodies by western blot analysis in 25 systemic lupus erythematosus patients. Six patients showed antibodies directed against nucleoporin p62. Our data indicate that p62 antibodies could be a useful additional marker in SLE. Bentham Open 2010-05-13 /pmc/articles/PMC2905771/ /pubmed/20648220 http://dx.doi.org/10.2174/1874312901004010024 Text en © Kraemer and Tony; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Kraemer, Doris M Tony, Hans-Peter Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus |
title | Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus |
title_full | Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus |
title_fullStr | Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus |
title_full_unstemmed | Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus |
title_short | Nuclear Pore Protein p62 Autoantibodies in Systemic Lupus Erythematosus |
title_sort | nuclear pore protein p62 autoantibodies in systemic lupus erythematosus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905771/ https://www.ncbi.nlm.nih.gov/pubmed/20648220 http://dx.doi.org/10.2174/1874312901004010024 |
work_keys_str_mv | AT kraemerdorism nuclearporeproteinp62autoantibodiesinsystemiclupuserythematosus AT tonyhanspeter nuclearporeproteinp62autoantibodiesinsystemiclupuserythematosus |