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How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration
Cell migration contributes to cancer metastasis and involves cell adhesion to the extracellular matrix (ECM), force generation through the cell's cytoskeletal, and finally cell detachment. Both adhesive cues from the ECM and soluble cues from neighbouring cells and tissue trigger intracellular...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905916/ https://www.ncbi.nlm.nih.gov/pubmed/20652046 http://dx.doi.org/10.1155/2010/363106 |
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author | Ngalim, Siti Hawa Magenau, Astrid Le Saux, Guillaume Gooding, J. Justin Gaus, Katharina |
author_facet | Ngalim, Siti Hawa Magenau, Astrid Le Saux, Guillaume Gooding, J. Justin Gaus, Katharina |
author_sort | Ngalim, Siti Hawa |
collection | PubMed |
description | Cell migration contributes to cancer metastasis and involves cell adhesion to the extracellular matrix (ECM), force generation through the cell's cytoskeletal, and finally cell detachment. Both adhesive cues from the ECM and soluble cues from neighbouring cells and tissue trigger intracellular signalling pathways that are essential for cell migration. While the machinery of many signalling pathways is relatively well understood, how hierarchies of different and conflicting signals are established is a new area of cellular cancer research. We examine the recent advances in microfabrication, microfluidics, and nanotechnology that can be utilized to engineer micro- and nanoscaled cellular environments. Controlling both adhesive and soluble cues for migration may allow us to decipher how cells become motile, choose the direction for migration, and how oncogenic transformations influences these decision-making processes. |
format | Text |
id | pubmed-2905916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-29059162010-07-22 How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration Ngalim, Siti Hawa Magenau, Astrid Le Saux, Guillaume Gooding, J. Justin Gaus, Katharina J Oncol Review Article Cell migration contributes to cancer metastasis and involves cell adhesion to the extracellular matrix (ECM), force generation through the cell's cytoskeletal, and finally cell detachment. Both adhesive cues from the ECM and soluble cues from neighbouring cells and tissue trigger intracellular signalling pathways that are essential for cell migration. While the machinery of many signalling pathways is relatively well understood, how hierarchies of different and conflicting signals are established is a new area of cellular cancer research. We examine the recent advances in microfabrication, microfluidics, and nanotechnology that can be utilized to engineer micro- and nanoscaled cellular environments. Controlling both adhesive and soluble cues for migration may allow us to decipher how cells become motile, choose the direction for migration, and how oncogenic transformations influences these decision-making processes. Hindawi Publishing Corporation 2010 2010-06-23 /pmc/articles/PMC2905916/ /pubmed/20652046 http://dx.doi.org/10.1155/2010/363106 Text en Copyright © 2010 Siti Hawa Ngalim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ngalim, Siti Hawa Magenau, Astrid Le Saux, Guillaume Gooding, J. Justin Gaus, Katharina How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration |
title | How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration |
title_full | How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration |
title_fullStr | How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration |
title_full_unstemmed | How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration |
title_short | How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration |
title_sort | how do cells make decisions: engineering micro- and nanoenvironments for cell migration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905916/ https://www.ncbi.nlm.nih.gov/pubmed/20652046 http://dx.doi.org/10.1155/2010/363106 |
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