ROCK as a Therapeutic Target of Diabetic Retinopathy

The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new phar...

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Detalles Bibliográficos
Autores principales: Arita, Ryoichi, Hata, Yasuaki, Ishibashi, Tatsuro
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905943/
https://www.ncbi.nlm.nih.gov/pubmed/20652057
http://dx.doi.org/10.1155/2010/175163
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author Arita, Ryoichi
Hata, Yasuaki
Ishibashi, Tatsuro
author_facet Arita, Ryoichi
Hata, Yasuaki
Ishibashi, Tatsuro
author_sort Arita, Ryoichi
collection PubMed
description The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new pharmacologic treatments are needed. This paper describes the relevance between Rho/ROCK pathway and the pathogenesis of diabetic retinopathy from its early to late stages. Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed.
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spelling pubmed-29059432010-07-22 ROCK as a Therapeutic Target of Diabetic Retinopathy Arita, Ryoichi Hata, Yasuaki Ishibashi, Tatsuro J Ophthalmol Review Article The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new pharmacologic treatments are needed. This paper describes the relevance between Rho/ROCK pathway and the pathogenesis of diabetic retinopathy from its early to late stages. Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed. Hindawi Publishing Corporation 2010 2010-06-21 /pmc/articles/PMC2905943/ /pubmed/20652057 http://dx.doi.org/10.1155/2010/175163 Text en Copyright © 2010 Ryoichi Arita et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Arita, Ryoichi
Hata, Yasuaki
Ishibashi, Tatsuro
ROCK as a Therapeutic Target of Diabetic Retinopathy
title ROCK as a Therapeutic Target of Diabetic Retinopathy
title_full ROCK as a Therapeutic Target of Diabetic Retinopathy
title_fullStr ROCK as a Therapeutic Target of Diabetic Retinopathy
title_full_unstemmed ROCK as a Therapeutic Target of Diabetic Retinopathy
title_short ROCK as a Therapeutic Target of Diabetic Retinopathy
title_sort rock as a therapeutic target of diabetic retinopathy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905943/
https://www.ncbi.nlm.nih.gov/pubmed/20652057
http://dx.doi.org/10.1155/2010/175163
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AT hatayasuaki rockasatherapeutictargetofdiabeticretinopathy
AT ishibashitatsuro rockasatherapeutictargetofdiabeticretinopathy

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