Cargando…

The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol

BACKGROUND: Ibuprofen and paracetamol differ in their mode of action and related therapeutic effects, suggesting that combined administration may offer improved analgesia. Reported here are the results of two studies on the pharmacokinetic properties of a novel ibuprofen (200 mg) and paracetamol (50...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanner, Trevor, Aspley, Sue, Munn, Andrew, Thomas, Tracy
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906415/ https://www.ncbi.nlm.nih.gov/pubmed/20602760 http://dx.doi.org/10.1186/1472-6904-10-10

Ejemplares similares

Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration
por: Atkinson, Hartley C., et al.
Publicado: (2015)

UV Spectrophotometric Simultaneous Determination of Paracetamol and Ibuprofen in Combined Tablets by Derivative and Wavelet Transforms
por: Hoang, Vu Dang, et al.
Publicado: (2014)

Randomized comparative trial of efficacy of paracetamol, ibuprofen and paracetamol-ibuprofen combination for treatment of febrile children
por: Vyas, Falgun Indravadan, et al.
Publicado: (2014)

Pharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets
por: Ghim, Jong-Lyul, et al.
Publicado: (2019)

Simultaneous Determination of Paracetamol, Ibuprofen, and Caffeine in Tablets by Molecular Absorption Spectroscopy Combined with Classical Least Square Method
por: Tran, Binh Thuc, et al.
Publicado: (2022)

Phase I Pharmacokinetic Study of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in Healthy Adult and Adolescent Populations
por: Tarabar, Sanela, et al.
Publicado: (2020)

Ibuprofen and Paracetamol: Acceptably Safe for All?
por: Pigazzani, Filippo, et al.
Publicado: (2018)

Effect of Paracetamol versus Ibuprofen in Adenotonsillectomy
por: Mirashrafi, Fatemeh, et al.
Publicado: (2021)

A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects
por: Park, Sang-In, et al.
Publicado: (2015)

Tramadol/paracetamol fixed-dose combination in the treatment of moderate to severe pain
por: Pergolizzi, Joseph V, et al.
Publicado: (2012)

Safety and pharmacokinetic profile of fixed-dose ivermectin with an innovative 18mg tablet in healthy adult volunteers
por: Muñoz, Jose, et al.
Publicado: (2018)

Pharmacokinetic similarity demonstrated after crushing of the elbasvir/grazoprevir fixed-dose combination tablet for HCV infection
por: Pijnenburg, Daniëlle W M, et al.
Publicado: (2020)

A clinical and safety review of paracetamol and ibuprofen in children
por: Kanabar, Dipak J.
Publicado: (2017)

Ibuprofène et paracétamol, promouvoir le bon usage
por: Malbos, Damien
Publicado: (2020)

Ibuprofen Sodium Is Absorbed Faster than Standard Ibuprofen Tablets: Results of Two Open-Label, Randomized, Crossover Pharmacokinetic Studies
por: Legg, Thomas J., et al.
Publicado: (2014)

Esophageal ulcer induced by ibuprofen tablets
por: Xu, Xiao-Ling, et al.
Publicado: (2016)

The Bioequivalence and Effect of Food on the Pharmacokinetics of a Fixed‐Dose Combination Tablet Containing Rosuvastatin and Ezetimibe in Healthy Japanese Subjects
por: Nishida, Chisato, et al.
Publicado: (2019)

Comparison of pharmacokinetics and safety of fixed-dose combination of SKI306X and aceclofenac versus separate tablets in healthy subjects
por: Meng, Xue, et al.
Publicado: (2017)

Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects
por: Cho, Yong-Soon, et al.
Publicado: (2018)

Capillary electrophoresis for the assay of fixed-dose combination tablets of artesunate and amodiaquine
por: Amin, N’Cho Christophe, et al.
Publicado: (2012)

Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus
por: Al-lawama, Manar, et al.
Publicado: (2017)

Pharmacokinetics of a Fixed-Dose Combination Product of Dapagliflozin and Linagliptin and Its Comparison with Co-Administration of Individual Tablets in Healthy Humans
por: Park, Jin-Woo, et al.
Publicado: (2022)

Bioequivalence of saxagliptin/dapagliflozin fixed‐dose combination tablets compared with coadministration of the individual tablets to healthy subjects
por: Vakkalagadda, Blisse, et al.
Publicado: (2016)

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children
por: Trippella, Giulia, et al.
Publicado: (2019)

Analgesic effect of oral paracetamol 1000 mg/ibuprofen 400 mg, paracetamol 1000 mg/codeine 60 mg, paracetamol 1000 mg/ibuprofen 400 mg/codeine 60 mg, or placebo on acute postoperative pain: a single-dose, randomized, and double-blind study
por: Lyngstad, Gaute, et al.
Publicado: (2023)

Tramadol/Paracetamol Fixed-Dose Combination for Chronic Pain Management in Family Practice: A Clinical Review
por: Morón Merchante, Ignacio, et al.
Publicado: (2013)

Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers
por: Laine, Loren, et al.
Publicado: (2012)

Isoniazid, Pyrazinamide and Rifampicin Content Variation in Split Fixed-Dose Combination Tablets
por: Pouplin, Thomas, et al.
Publicado: (2014)

Ibuprofen enantiomers in premature neonates with patent ductus arteriosus: Preliminary data on an unexpected pharmacokinetic profile of S(+)‐ibuprofen
por: Padrini, Roberto, et al.
Publicado: (2021)

Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
por: Hay, Alastair D, et al.
Publicado: (2008)

Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
Publicado: (2009)

Organic micropollutants paracetamol and ibuprofen—toxicity, biodegradation, and genetic background of their utilization by bacteria
por: Żur, Joanna, et al.
Publicado: (2018)

Evaluation of Fixed-Dose Combinations of Ibuprofen and Acetaminophen in the Treatment of Postsurgical Dental Pain: A Pilot, Dose-Ranging, Randomized Study
por: Kellstein, David, et al.
Publicado: (2020)

Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach
por: Kanwal, Ummarah, et al.
Publicado: (2021)

Simultaneous Spectrophotometric Determination of Drotaverine Hydrochloride and Paracetamol in Tablet
por: Mahaparale, Sonali, et al.
Publicado: (2010)

Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets
por: Zhao, Qinying, et al.
Publicado: (2014)

Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability
por: Dennison, Thomas J, et al.
Publicado: (2017)

Pharmacokinetics of fixed-dose combination of rosuvastatin 20 mg and ezetimibe 10 mg compared to concurrent administration of individual tablets in healthy Korean subjects
por: Hwang, Inyoung, et al.
Publicado: (2018)

Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol
por: Tan, Eunicia, et al.
Publicado: (2020)

Analgesic activity of fixed dose combinations of paracetamol with diclofenac sodium and paracetamol with tramadol on different pain models in healthy volunteers - A randomized double blind crossover study
por: Tripathi, Sachidanand, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_03q30qvdbfqng06og9bct67tqn