Regulation of lipid droplet turnover by ubiquitin ligases

Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ub...

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Detalles Bibliográficos
Autores principales: Alberts, Philipp, Rotin, Daniela
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906420/
https://www.ncbi.nlm.nih.gov/pubmed/20646264
http://dx.doi.org/10.1186/1741-7007-8-94
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author Alberts, Philipp
Rotin, Daniela
author_facet Alberts, Philipp
Rotin, Daniela
author_sort Alberts, Philipp
collection PubMed
description Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ubiquitination and degradation of droplet-associated proteins. A deficiency of spartin apparently causes lipid droplets to accumulate. See research article: http://www.biomedcentral.com/1741-7007/8/72/
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spelling pubmed-29064202010-07-20 Regulation of lipid droplet turnover by ubiquitin ligases Alberts, Philipp Rotin, Daniela BMC Biol Commentary Mutation of the protein spartin is a cause of one form of spastic paraplegia. Spartin interacts with ubiquitin ligases of the Nedd4 family, and a recent report in BMC Biology now shows that it acts as an adaptor to recruit and activate the ubiquitin ligase AIP4 onto lipid droplets, leading to the ubiquitination and degradation of droplet-associated proteins. A deficiency of spartin apparently causes lipid droplets to accumulate. See research article: http://www.biomedcentral.com/1741-7007/8/72/ BioMed Central 2010-07-19 /pmc/articles/PMC2906420/ /pubmed/20646264 http://dx.doi.org/10.1186/1741-7007-8-94 Text en Copyright ©2010 Alberts and Rotin; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Alberts, Philipp
Rotin, Daniela
Regulation of lipid droplet turnover by ubiquitin ligases
title Regulation of lipid droplet turnover by ubiquitin ligases
title_full Regulation of lipid droplet turnover by ubiquitin ligases
title_fullStr Regulation of lipid droplet turnover by ubiquitin ligases
title_full_unstemmed Regulation of lipid droplet turnover by ubiquitin ligases
title_short Regulation of lipid droplet turnover by ubiquitin ligases
title_sort regulation of lipid droplet turnover by ubiquitin ligases
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906420/
https://www.ncbi.nlm.nih.gov/pubmed/20646264
http://dx.doi.org/10.1186/1741-7007-8-94
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AT rotindaniela regulationoflipiddropletturnoverbyubiquitinligases

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