Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors

BACKGROUND: Aneuploidy, centrosome abnormalities and gene amplification are hallmarks of chromosome instability (CIN) in cancer. Yet there are no studies of the in vivo behavior of these phenomena within the same bladder tumor. METHODS: Twenty-one paraffin-embedded bladder tumors were analyzed by co...

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Detalles Bibliográficos
Autores principales: del Rey, Javier, Prat, Esther, Ponsa, Immaculada, Lloreta, Josep, Gelabert, Antoni, Algaba, Ferran, Camps, Jordi, Miró, Rosa
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906479/
https://www.ncbi.nlm.nih.gov/pubmed/20540739
http://dx.doi.org/10.1186/1471-2407-10-280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906479/
https://www.ncbi.nlm.nih.gov/pubmed/20540739
http://dx.doi.org/10.1186/1471-2407-10-280

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