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Distinct Roles for Laminin Globular Domains in Laminin α1 Chain Mediated Rescue of Murine Laminin α2 Chain Deficiency

BACKGROUND: Laminin α2 chain mutations cause congenital muscular dystrophy with dysmyelination neuropathy (MDC1A). Previously, we demonstrated that laminin α1 chain ameliorates the disease in mice. Dystroglycan and integrins are major laminin receptors. Unlike laminin α2 chain, α1 chain binds the re...

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Detalles Bibliográficos
Autores principales:	Gawlik, Kinga I., Åkerlund, Mikael, Carmignac, Virginie, Elamaa, Harri, Durbeej, Madeleine
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906511/ https://www.ncbi.nlm.nih.gov/pubmed/20657839 http://dx.doi.org/10.1371/journal.pone.0011549

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