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Persistent Expression of Biologically Active Anti-HER2 Antibody by AAVrh.10-mediated Gene Transfer

Trastuzumab (Herceptin) is a recombinant humanized monoclonal antibody directed against an extracellular region of the HER2 protein. We hypothesized that a single adeno-associated virus mediated genetic delivery of an anti-HER2 antibody should be effective in mediating long term production of anti-H...

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Detalles Bibliográficos
Autores principales:	Wang, Guoqing, Qiu, Jianping, Wang, Rui, Krause, Anja, Boyer, Julie L., Hackett, Neil R., Crystal, Ronald G.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906671/ https://www.ncbi.nlm.nih.gov/pubmed/20448672 http://dx.doi.org/10.1038/cgt.2010.11

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