Minor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1,N(2)-γ-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage,

[Image: see text] DNA−protein conjugates are potentially repaired via proteolytic digestion to DNA−peptide conjugates. The latter have been modeled with the amino-terminal lysine of the peptide KWKK conjugated via a trimethylene linkage to the N(2)-dG amine positioned in 5′-d(GCTAGCXAGTCC)-3′·5′-d(G...

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Detalles Bibliográficos
Autores principales: Huang, Hai, Kozekov, Ivan D., Kozekova, Albena, Rizzo, Carmelo J., McCullough, Amanda K., Lloyd, R. Stephen, Stone, Michael P.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907095/
https://www.ncbi.nlm.nih.gov/pubmed/20604523
http://dx.doi.org/10.1021/bi100364f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907095/
https://www.ncbi.nlm.nih.gov/pubmed/20604523
http://dx.doi.org/10.1021/bi100364f

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