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Minor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1,N(2)-γ-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage,
[Image: see text] DNA−protein conjugates are potentially repaired via proteolytic digestion to DNA−peptide conjugates. The latter have been modeled with the amino-terminal lysine of the peptide KWKK conjugated via a trimethylene linkage to the N(2)-dG amine positioned in 5′-d(GCTAGCXAGTCC)-3′·5′-d(G...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907095/ https://www.ncbi.nlm.nih.gov/pubmed/20604523 http://dx.doi.org/10.1021/bi100364f |