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Modifying 5-HT1A Receptor Gene Expression as a New Target for Antidepressant Therapy
Major depression is the most common form of mental illness, and is treated with antidepressant compounds that increase serotonin (5-HT) neurotransmission. Increased 5-HT1A autoreceptor levels in the raphe nuclei act as a “brake” to inhibit the 5-HT system, leading to depression and resistance to ant...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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Frontiers Research Foundation
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907233/ https://www.ncbi.nlm.nih.gov/pubmed/20661455 http://dx.doi.org/10.3389/fnins.2010.00035 |