The Compartmentalisation of Phosphorylated Free Oligosaccharides in Cells from a CDG Ig Patient Reveals a Novel ER-to-Cytosol Translocation Process

BACKGROUND: Biosynthesis of the dolichol linked oligosaccharide (DLO) required for protein N-glycosylation starts on the cytoplasmic face of the ER to give Man(5)GlcNAc(2)-PP-dolichol, which then flips into the ER for further glycosylation yielding mature DLO (Glc(3)Man(9)GlcNAc(2)-PP-dolichol). Aft...

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Detalles Bibliográficos
Autores principales: Peric, Delphine, Durrant-Arico, Christelle, Delenda, Christophe, Dupré, Thierry, De Lonlay, Pascale, de Baulny, Hélène Ogier, Pelatan, Cécile, Bader-Meunier, Brigitte, Danos, Olivier, Chantret, Isabelle, Moore, Stuart E. H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907391/
https://www.ncbi.nlm.nih.gov/pubmed/20652024
http://dx.doi.org/10.1371/journal.pone.0011675

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